Ngaovithunvong Varisara, Wanlapakorn Nasamon, Tesapirat Lita, Suratannon Narrissara, Poovorawan Yong
Faculty of Medicine, Chulalongkorn University, Pathumwan, Bangkok, Thailand.
J Infect Dev Ctries. 2016 Aug 2;10(7):735-40. doi: 10.3855/jidc.7560.
mumps vaccination implementation in the form of MMR - measles, mumps, and rubella) in Thailand for first-grade school students since 1997 and for infants 9-12 months of age since 2010 resulted in a dramatic decline in the incidence of and deaths from mumps. However, there has been a resurgence of mumps outbreaks in Thailand, even in vaccinated populations.
We aimed to determine the current seroprevalence of IgG antibodies to mumps in those 0-60 years of age from four different geographic areas of Thailand, and compare the results with our previous serosurvey in 2004.
Seropositivity rates in children 0-7 years of age increased significantly from 45.8% in 2004 to 72.3% in 2014 after the launch of the MMR vaccine for infants. In the 8-14-year age group who had received one dose of mumps vaccination, the seropositivity rate was 66.7%. In the 15-19-year age group the seropositivity rate was the lowest, at 52.5%.
Our findings correspond well with the vaccination schedules, as the highest seropositivity rate was found in children between 0 and 7 years of age. For those older than 7, there was a decline in seropositivity rate despite good vaccine coverage and reached its lowest in the 15-19-year age group. This suggested that certain population groups might be incompletely vaccinated, or the humoral immunity provided by vaccination gradually declined over time.
We recommend a booster dose of MMR vaccine for Thai adolescents in order to prevent future mumps outbreaks.
自1997年起，泰国对一年级学生采用MMR（麻疹、腮腺炎和风疹）形式进行腮腺炎疫苗接种，自2010年起对9至12个月大的婴儿进行接种，这使得腮腺炎的发病率和死亡率大幅下降。然而，泰国甚至在已接种疫苗的人群中也出现了腮腺炎疫情的复发。
我们旨在确定泰国四个不同地理区域0至60岁人群中腮腺炎IgG抗体的当前血清阳性率，并将结果与我们2004年之前的血清学调查进行比较。
在为婴儿接种MMR疫苗后，0至7岁儿童的血清阳性率从2004年的45.8%显著提高到2014年的72.3%。在接种过一剂腮腺炎疫苗的8至14岁年龄组中，血清阳性率为66.7%。在15至19岁年龄组中，血清阳性率最低，为52.5%。
我们的研究结果与疫苗接种计划相符，因为在0至7岁儿童中发现了最高的血清阳性率。对于7岁以上的人群，尽管疫苗接种覆盖率良好，但血清阳性率仍有所下降，并在15至19岁年龄组中降至最低。这表明某些人群可能接种不完全，或者疫苗接种提供的体液免疫会随着时间逐渐下降。
我们建议为泰国青少年接种一剂MMR疫苗加强针，以预防未来的腮腺炎疫情。
