Iorizzo Matilde, Oranje Arnold P
a Private Dermatology Practice , Bellinzona , Switzerland.
b Kinderhuid.nl, Rotterdam & Hair Outpatient Clinic , Breda & Dermicis Skin Clinic , Alkmaar , the Netherlands.
Expert Opin Pharmacother. 2016 Sep;17(13):1767-73. doi: 10.1080/14656566.2016.1217990. Epub 2016 Aug 9.
Treatment options for hair disorders are generally very limited. These options are even more limited in children due to the lack of trials and clinical research. Moreover, physicians are sometimes scared to treat children with drugs without safety data, especially because most hair disorders are benign.
The objective of this paper is to review current and future treatments for alopecia areata and trichotillomania, two disorders that are sometimes encountered in differential diagnosis or even occur together and probably affect the mental condition of the patient involved more than others.
Hair disorders are very stressful in paediatric population. Both physicians and families are often unsatisfied leading to non-compliance. New drugs with less side- effects are needed to increase the percentage of cure. It is also crucial to refine genetic studies on alopecia areata in order to identify new potential drugs worth studying. Moreover, studies on trichotillomania should not be evaluated only by psychiatrics, but also by dermatologists.
毛发疾病的治疗选择通常非常有限。由于缺乏试验和临床研究，这些选择在儿童中更为有限。此外，医生有时不敢在没有安全数据的情况下用药物治疗儿童，尤其是因为大多数毛发疾病是良性的。
本文的目的是综述斑秃和拔毛癖的当前及未来治疗方法，这两种疾病有时在鉴别诊断中会遇到，甚至会同时出现，并且可能比其他疾病更影响患者的精神状况。
毛发疾病在儿科人群中压力很大。医生和家庭往往都不满意，导致治疗依从性差。需要副作用更小的新药来提高治愈率。完善斑秃的基因研究以确定值得研究的新潜在药物也至关重要。此外，对拔毛癖的研究不应仅由精神科医生评估，皮肤科医生也应参与评估。
