Perfumi M, Massi M, Costa G, Epstein A N, de Caro G
Institute of Pharmacology, University of Camerino, Italy.
Peptides. 1989 Jan-Feb;10(1):125-30. doi: 10.1016/0196-9781(89)90088-0.
In infant rats, kassinin exerts its antidipsogenic effect in the very early stages of neonatal life (2nd-3rd day). The inhibition of cell-dehydration drinking appears in rats of 2 days, and attains adult levels in pups of 9 days. Instead, the thirsts induced by suckling deprivation or by intracerebroventricular angiotensin II are inhibited by kassinin precociously (3rd day), but are unaffected by it in rats of 12-15 days. Kassinin also inhibits milk intake very early (3rd day) and this effect also disappears at 12 days of age. The pattern of ontogenetic results described here may be that of a brain kassinin-like tachykinin that, in the course of the development of the neural structures on which it acts, gains potent and selective control of cell-dehydration thirst.
在幼鼠中，速激肽在新生生命的早期阶段（第2 - 3天）发挥其抗渴作用。细胞脱水饮水的抑制作用在2日龄的大鼠中出现，并在9日龄的幼崽中达到成年水平。相反，由吸吮剥夺或脑室内注射血管紧张素II诱导的口渴在较早阶段（第3天）就被速激肽抑制，但在12 - 15日龄的大鼠中不受其影响。速激肽也在很早的时候（第3天）就抑制乳汁摄入，这种作用在12日龄时也消失。这里描述的个体发育结果模式可能是大脑中类似速激肽的速激肽的模式，在其作用的神经结构发育过程中，获得对细胞脱水口渴的有效且选择性的控制。
