脑室内注射铅对脱水或中枢胆碱能及血管紧张素能刺激诱导的大鼠饮水行为的急性影响。

Acute effect of intracerebroventricular administration of lead on the drinking behavior of rats induced by dehydration or central cholinergic and angiotensinergic stimulation.

作者信息

Fregoneze J B, Cunha M, Bulcão C, Ferreira H, de Castro e Silva E

机构信息

Department of Zoology, Federal University of Bahia, Brazil.

出版信息

Physiol Behav. 1994 Jul;56(1):129-33. doi: 10.1016/0031-9384(94)90270-4.

DOI:10.1016/0031-9384(94)90270-4

PMID:8084891

Abstract

In the present paper, the acute effect of third ventricle injections of lead acetate (5, 10, 100, 1000 ng/rat) on the drinking behavior of adult, male, Wistar rats was investigated. Lead generates a prompt and significant reduction in water intake induced by three different circumstances: dehydration (14 h of water deprivation) and after carbachol (2 micrograms/rat, ICV) or angiotensin II (10 ng/rat, ICV) administration. These results show that lead may produce very fast actions in the central nervous system and suggest that inhibition of water intake by lead may depend on impairment of central cholinergic and/or angiotensinergic functions.

摘要

在本论文中，研究了向成年雄性Wistar大鼠第三脑室注射醋酸铅（5、10、100、1000纳克/大鼠）对其饮水行为的急性影响。铅在三种不同情况下可迅速且显著地减少水摄入量：脱水（剥夺水分14小时）以及在给予卡巴胆碱（2微克/大鼠，脑室内注射）或血管紧张素II（10纳克/大鼠，脑室内注射）之后。这些结果表明，铅可能在中枢神经系统中产生非常快速的作用，并提示铅对水摄入的抑制作用可能取决于中枢胆碱能和/或血管紧张素能功能的损害。