颅内注射速激肽对猫血管紧张素诱导饮水的抑制作用。

Inhibitory effect of intracranial injections of tachykinins on angiotensin-induced drinking in the cat.

作者信息

Barocelli E, Chiavarini M, Impicciatore M, Massi M, de Caro G

机构信息

Institute of Pharmacology and Pharmacognosy, University of Parma, Italy.

出版信息

Pharmacol Biochem Behav. 1988 Oct;31(2):493-7. doi: 10.1016/0091-3057(88)90379-6.

DOI:10.1016/0091-3057(88)90379-6

PMID:2469087

Abstract

The tachykinins eledoisin, substance P and kassinin were administered by pulse intracerebroventricular (ICV) injections to cats made thirsty by ICV angiotensin II, 100 ng per cat. Eledoisin, 100 ng per cat, produced an inhibition of drinking which was larger (56.0 vs. 45.2%) and lasted longer than that evoked by 400 ng per cat of substance P. Kassinin, 100 ng per cat, did not evoke any effect at all. The treatment with these peptides neither produced signs of discomfort nor induced any other behavioural alteration. The results of present experiments suggest that the antidipsogenic effect of tachykinins is a phenomenon of general interest among mammals.

摘要

将速激肽异速肽、P物质和卡西宁通过脉冲式脑室内（ICV）注射给予经ICV注射100 ng/只血管紧张素II而致渴的猫。每只猫注射100 ng异速肽可产生饮水抑制，其抑制程度（56.0%对45.2%）大于每只猫注射400 ng P物质所引起的抑制，且持续时间更长。每只猫注射100 ng卡西宁则根本没有引起任何效应。用这些肽进行处理既未产生不适迹象，也未诱发任何其他行为改变。本实验结果表明，速激肽的抗饮水作用是哺乳动物中普遍感兴趣的一种现象。