Clevenger Tracy N, Luna Gabriel, Fisher Steven K, Clegg Dennis O
Center for Stem Cell Biology & Engineering, University of California, Santa Barbara, CA, USA.
Neuroscience Research Institute, University of California, Santa Barbara, CA, USA.
Regen Med. 2016 Sep;11(6):589-99. doi: 10.2217/rme-2016-0064. Epub 2016 Aug 3.
Regenerative medicine possesses the potential to ameliorate damage to tissue that results from a vast range of conditions, including traumatic injury, tumor resection and inherited tissue defects. Adult stem cells, while more limited in their potential than pluripotent stem cells, are still capable of differentiating into numerous lineages and provide feasible allogeneic and autologous treatment options for many conditions. Adipose stem cells are one of the most abundant types of stem cell in the adult human. Here, we review recent advances in the development of synthetic scaffolding systems used in concert with adipose stem cells and assess their potential use for clinical applications.
再生医学有潜力改善由多种情况导致的组织损伤,这些情况包括创伤性损伤、肿瘤切除和遗传性组织缺陷。成体干细胞虽然其潜能比多能干细胞更有限,但仍能够分化为多种细胞谱系,并为许多病症提供可行的异体和自体治疗选择。脂肪干细胞是成年人体内最丰富的干细胞类型之一。在此,我们综述了与脂肪干细胞协同使用的合成支架系统开发方面的最新进展,并评估了它们在临床应用中的潜在用途。