Castel M N, Stutzmann J M, Lucas M, Lafforgue J, Blanchard J C
Département Biologie, Centre de Recherches de Vitry, Vitry sur Seine, France.
Peptides. 1989 Jan-Feb;10(1):95-101. doi: 10.1016/0196-9781(89)90083-1.
The electroencephalographic (EEG) effects of the ICV administration of neurotensin (NT 1-13), NT 1-8 (an inactive neurotensin fragment) and D TYR-11 NT (a long-lasting analog of neurotensin) were studied in rats. In awake rats, NT 1-13 (30 micrograms) and D TYR-11 NT (10 micrograms) induced an increase of the power spectrum in the theta range activity (4-7 Hz). In rats recorded during the sleep-wakefulness cycles, NT 1-13 (10 and 30 micrograms) and D TYR-11 NT (10 micrograms) had an awakening effect and also induced an increase of latency to the first episode of the different sleep stages (intermediate stage and slow wave sleep). NT 1-8 (30 and 90 micrograms in awake rats, 10 and 90 micrograms for sleep-wakefulness cycles) was inactive in all these experiments. Thus, it seems that all these effects can be linked to neurotensin receptors; indeed only fragments which recognize receptors possess an EEG activity.
研究了向大鼠脑室内注射神经降压素（NT 1-13）、NT 1-8（一种无活性的神经降压素片段）和D-TYR-11 NT（神经降压素的长效类似物）对脑电图（EEG）的影响。在清醒大鼠中，NT 1-13（30微克）和D-TYR-11 NT（10微克）可使θ波范围活动（4-7赫兹）的功率谱增加。在睡眠-觉醒周期记录的大鼠中，NT 1-13（10和30微克）和D-TYR-11 NT（10微克）具有觉醒作用，还可延长不同睡眠阶段（中间阶段和慢波睡眠）首次发作的潜伏期。在所有这些实验中，NT 1-8（清醒大鼠中为30和90微克，睡眠-觉醒周期中为10和90微克）均无活性。因此，似乎所有这些效应都与神经降压素受体有关；实际上，只有能识别受体的片段才具有脑电图活性。
