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本文引用的文献

1
HMGA2 overexpression plays a critical role in the progression of esophageal squamous carcinoma.HMGA2过表达在食管鳞状细胞癌进展中起关键作用。
Oncotarget. 2016 May 3;7(18):25872-84. doi: 10.18632/oncotarget.8288.
2
Epidemiology, Diagnosis, and Management of Esophageal Adenocarcinoma.食管腺癌的流行病学、诊断与管理
Gastroenterology. 2015 Aug;149(2):302-17.e1. doi: 10.1053/j.gastro.2015.04.053. Epub 2015 May 7.
3
HMGA1-pseudogene expression is induced in human pituitary tumors.HMGA1假基因表达在人类垂体肿瘤中被诱导。
Cell Cycle. 2015;14(9):1471-5. doi: 10.1080/15384101.2015.1021520.
4
High mobility group a proteins as tumor markers.高迁移率族蛋白 A 作为肿瘤标志物。
Front Med (Lausanne). 2015 Mar 25;2:15. doi: 10.3389/fmed.2015.00015. eCollection 2015.
5
Detection of high mobility group A2 specific mRNA in the plasma of patients affected by epithelial ovarian cancer.上皮性卵巢癌患者血浆中高迁移率族蛋白A2特异性mRNA的检测
Oncotarget. 2015 Aug 7;6(22):19328-35. doi: 10.18632/oncotarget.2896.
6
Global incidence of oesophageal cancer by histological subtype in 2012.2012 年按组织学亚型划分的全球食管癌发病率。
Gut. 2015 Mar;64(3):381-7. doi: 10.1136/gutjnl-2014-308124. Epub 2014 Oct 15.
7
HMGA1 pseudogenes as candidate proto-oncogenic competitive endogenous RNAs.HMGA1假基因作为候选的原癌基因竞争性内源RNA
Oncotarget. 2014 Sep 30;5(18):8341-54. doi: 10.18632/oncotarget.2202.
8
HMGA1 silencing restores normal stem cell characteristics in colon cancer stem cells by increasing p53 levels.HMGA1基因沉默通过提高p53水平来恢复结肠癌干细胞的正常干细胞特性。
Oncotarget. 2014 May 30;5(10):3234-45. doi: 10.18632/oncotarget.1914.
9
Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation.用于医学诊断测试评估的受试者工作特征（ROC）曲线分析。
Caspian J Intern Med. 2013 Spring;4(2):627-35.
10
The potential of molecular markers to improve interventions through the natural history of oesophageal squamous cell carcinoma.分子标志物提高食管鳞癌自然史干预效果的潜力。
Biosci Rep. 2013 Aug 14;33(4):e00057. doi: 10.1042/BSR20130063.

食管癌中的高迁移率族A蛋白

High Mobility Group A proteins in esophageal carcinomas.

作者信息

Palumbo Júnior Antonio, Da Costa Nathalia Meireles, Esposito Francesco, Fusco Alfredo, Pinto Luis Felipe Ribeiro

机构信息

a Programa de Carcinogênese Molecular, Instituto Nacional de Câncer - INCA, Rua André Cavalcanti , Rio de Janeiro , RJ , Brazil.

b Laboratório de Interações Celulares, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro Prédio de Ciências da Saúde - Cidade Universitária, Ilha do Fundão, A. Carlos Chagas , Rio de Janeiro , RJ , Brasil.

出版信息

Cell Cycle. 2016 Sep 16;15(18):2410-3. doi: 10.1080/15384101.2016.1215388. Epub 2016 Aug 2.

DOI:10.1080/15384101.2016.1215388
PMID:27484584
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5026802/
Abstract

We have recently shown that HMGA2 is overexpressed in esophageal squamous cell carcinoma (ESCC) and its detection allows to discriminate between cancer and normal surrounding tissue proposing HMGA2 as a novel diagnostic marker. Interestingly, esophageal adenocarcinoma shows an opposite behavior with the overexpression of HMGA1 but not HMGA2. Moreover, we show that the suppression of HMGA2 in 2 ESCC cell lines reduces the malignant phenotype. Then, this paper highlights a differential induction of the HMGA proteins, depending on the cancer histological type, and reinforces the perspective of an innovative esophageal cancer therapy based on the suppression of the HMGA protein function and/or expression.

摘要

我们最近发现，HMGA2在食管鳞状细胞癌（ESCC）中过度表达，检测该蛋白有助于区分癌组织与周围正常组织，这表明HMGA2可作为一种新型诊断标志物。有趣的是，食管腺癌却呈现相反的情况，即HMGA1过度表达而HMGA2未过度表达。此外，我们发现抑制两种ESCC细胞系中的HMGA2可降低其恶性表型。因此，本文强调了HMGA蛋白的诱导存在差异，这取决于癌症的组织学类型，并强化了基于抑制HMGA蛋白功能和/或表达的创新性食管癌治疗前景。