Lee Aimee, Pickham David
Cardiac Electrophysiology, Stanford Health Care, 300 Pasteur Drive, Stanford, CA 94305, USA.
General Medical Disciplines, Stanford Medicine, Stanford, CA, USA.
Crit Care Nurs Clin North Am. 2016 Sep;28(3):357-71. doi: 10.1016/j.cnc.2016.04.007. Epub 2016 Jun 22.
Drugs can be a double-edged sword, providing the benefit of symptom alleviation and disease modification but potentially causing harm from adverse cardiac arrhythmic events. Proarrhythmia is the ability of a drug to cause an arrhythmia, the number one reason for drugs to be withdrawn from the patient. Drug-induced arrhythmias are defined as the production of de novo arrhythmias or aggravation of existing arrhythmias, as a result of previous or concomitant pharmacologic treatment. This review summarizes normal cardiac cell and tissue functioning and provides an overview of drugs that effect cardiac repolarization and the adverse effects of commonly administered antiarrhythmics.
药物可能是一把双刃剑，既能缓解症状和改善病情，又可能因不良心律失常事件而造成伤害。促心律失常作用是指药物导致心律失常的能力，这是药物被撤用的首要原因。药物性心律失常被定义为由于先前或同时进行的药物治疗而产生的新发心律失常或使现有心律失常加重。本综述总结了正常心脏细胞和组织的功能，并概述了影响心脏复极化的药物以及常用抗心律失常药物的不良反应。
