Vogin Guillaume, Golfier François, Hajri Touria, Leroux Agnès, Weber Béatrice
Department of Radiation Oncology, Institut de Cancérologie de Lorraine, Avenue de Bourgogne, 54500, Vandoeuvre Les Nancy, France.
Department of Obstetrics and Gynaecology, Lyon Sud University Hospital, Lyon, France.
BMC Cancer. 2016 Aug 2;16:573. doi: 10.1186/s12885-016-2641-2.
HELLP syndrome is a combination of symptoms described as hemolysis, elevated liver enzymes and low platelets, that complicates 0.01-0.6 % of pregnancies. HELLP syndrome has been scarcely reported associated with partial moles, another rare complication of pregnancy. This manuscript describes the only reported case of HELLP syndrome associated with a complete invasive hydatiform mole.
We report a perimenopausal patient in prolonged remission from an uncommon high-risk invasive complete mole. The diagnosis was set in a context of early onset preeclampsia and HELLP syndrome. The development of life-threatening complications required primary hysterectomy. Postoperative hCG quickly returned to normal with EMA/CO multi-agent chemotherapy.
Our patient is in prolonged remission from a complete mole complicated with EOP and HELLP syndrome. This exceptional case of complicated gestational trophoblastic neoplasia reflects a very rare condition in which several risk factors for placental ischemia are associated. Emergency hysterectomy should be considered as salvage initial treatment in such life-threatening situations.
