Institute of Liver Studies, King's College Hospital, London, UK.
Lancet. 2010 Feb 13;375(9714):594-605. doi: 10.1016/S0140-6736(09)61495-1.
Severe liver disease in pregnancy is rare. Pregnancy-related liver disease is the most frequent cause of liver dysfunction in pregnancy and provides a real threat to fetal and maternal survival. A rapid diagnosis differentiating between liver disease related and unrelated to pregnancy is required in women who present with liver dysfunction during pregnancy. Research has improved our understanding of the pathogenesis of pregnancy-related liver disease, which has translated into improved maternal and fetal outcomes. Here, we provide an overview of liver diseases that occur in pregnancy, an update on the key mechanisms involved in their pathogenesis, and assessment of available treatment options.
妊娠期严重肝病罕见。妊娠相关肝病是妊娠期间肝功能障碍最常见的原因，对胎儿和母亲的生存构成严重威胁。对于在妊娠期间出现肝功能障碍的女性，需要快速诊断其肝疾病与妊娠是否相关。研究提高了我们对妊娠相关肝病发病机制的认识，这转化为改善了母婴结局。在此，我们概述了妊娠期间发生的肝病，更新了其发病机制中涉及的关键机制，并评估了现有治疗选择。
