Priĭmak A A, Borisova M I, Smirnova N A, Kremer O V, Kruglova E G
Probl Tuberk. 1989(5):46-50.
The mechanism of sodium oxybutyrate effect on the lung vessels under normal conditions and under conditions of experimental tuberculosis in dogs was studied by the time course of pressure in the pulmonary artery and the content of serotonin, histamine and adenosine in blood of the aorta and pulmonary artery after the drug intravenous administration. To confirm the antihypoxic effect of sodium oxybutyrate, the levels of lactate, pyruvate, ATP, ADP and AMP were investigated. The levels of adenosine were judged indirectly by the activity of 5-nucleotidase, adenosine desaminase and AMP. It was shown that the decrease in pressure in the pulmonary artery after the use of sodium oxybutyrate was connected with the drug antihypoxic effect which led to lower levels of histamine in the aorta blood under the normal conditions and to higher levels of adenosine under the conditions of tuberculosis.
通过静脉注射药物后肺动脉压力的时程变化以及主动脉和肺动脉血液中血清素、组胺和腺苷的含量，研究了在正常条件下和实验性犬结核病条件下，丁酸钠对肺血管的作用机制。为了证实丁酸钠的抗缺氧作用，研究了乳酸、丙酮酸、三磷酸腺苷（ATP）、二磷酸腺苷（ADP）和一磷酸腺苷（AMP）的水平。腺苷水平通过5-核苷酸酶、腺苷脱氨酶和AMP的活性间接判断。结果表明，使用丁酸钠后肺动脉压力降低与药物的抗缺氧作用有关，在正常条件下该作用导致主动脉血液中组胺水平降低，在结核病条件下导致腺苷水平升高。
