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[乙替米唑与羟基丁酸钠对慢性缺氧新生儿代偿适应能力的影响]

[Effect of etimizol and sodium hydroxybutyrate on the compensatory-adaptive capabilities of newborns with chronic hypoxia].

作者信息

Tarakhovskiĭ M L, Zadorozhnaia T D, Tishchenko V K, Tsypkun A G

出版信息

Farmakol Toksikol. 1978 Nov-Dec;41(6):686-90.

PMID:569076
Abstract

Daily injections of 5 mg/kg of aethimizol to female rabbits during the last week of pregnancy results in normalization of the central nervous and cardiovascular systems reactions in response to a graded mechanical stimulation, in an increased ATP content in the erythrocytes, lesser acidotonic shifts in the blood and marked diminution in the number of stillbirths. Under similar conditions of the exeriment sodium oxybutyrate in a dose of 200 mg/kg did not contribute to normalization of the central nervous and cardiovascular systems response reactions, nor did it lower the acidosis in the blood and had no marked effect on the reduction in the number of stillbirths.

摘要

在怀孕最后一周,每天给雌性兔子注射5毫克/千克的乙硫咪唑,可使中枢神经系统和心血管系统对分级机械刺激的反应恢复正常,红细胞中的三磷酸腺苷(ATP)含量增加,血液中的酸渗性变化减小,死产数量显著减少。在类似的实验条件下,剂量为200毫克/千克的羟丁酸钠无助于中枢神经系统和心血管系统反应的正常化,也不能降低血液中的酸中毒,对减少死产数量没有显著影响。

相似文献

1
[Effect of etimizol and sodium hydroxybutyrate on the compensatory-adaptive capabilities of newborns with chronic hypoxia].[乙替米唑与羟基丁酸钠对慢性缺氧新生儿代偿适应能力的影响]
Farmakol Toksikol. 1978 Nov-Dec;41(6):686-90.
2
[Effect of etimizol on the adaptive potentialities of the body of newborn rabbits that have experienced chronic intrauterine hypoxia].[乙替米唑对经历慢性子宫内缺氧的新生兔机体适应潜能的影响]
Fiziol Zh. 1975 Nov-Dec;21(6):795-9.
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[Sodium oxybutyrate normalizes the central nervous system functions in the progeny of rats subjected to hypobaric hypoxia during pregnancy].
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[Prophylactic and therapeutic action of etimizol on the change in myocardial tissue metabolism in a neurogenic lesion].
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[Effect of sodium oxybutyrate on metabolic indices in ischemic hypoxia of muscle tissue].[羟丁酸钠对肌肉组织缺血缺氧时代谢指标的影响]
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Biull Eksp Biol Med. 1985 Sep;100(9):317-9.