糖尿病与单纯疱疹性眼病的关系。

The Association between Diabetes and Herpes Simplex Eye Disease.

机构信息

a Cornea Service, Wills Eye Hospital , Jefferson Medical College of Thomas Jefferson University , Philadelphia , Pennsylvania , USA.

b Cornea Service, Department of Ophthalmology , Dıskapı Yıldırım Beyazıt Training and Research Hospital , Ankara , Turkey.

出版信息

Ocul Immunol Inflamm. 2018;26(1):125-129. doi: 10.1080/09273948.2016.1189576. Epub 2016 Aug 2.

DOI:10.1080/09273948.2016.1189576

PMID:27485702

Abstract

PURPOSE

To evaluate the association between diabetes mellitus (DM) and presence and severity of Herpes simplex eye disease (HSED).

METHODS

We conducted two sub-studies. We included the patients seen on the Cornea Service of the Wills Eye Hospital from January 2008 to August 2012. Study 1 included 541 patients with HSED and 3226 controls. Study 2 involved 40 diabetic and 120 non-diabetic ocular surface HSED patients. Severity of ocular surface HSED was graded as mild, moderate, or severe, based on best-corrected visual acuity (BCVA). Patients were excluded if they had fewer than two office visits or had non-Herpes simplex-related vision-threatening conditions. Diabetes was graded as: diet group (DM controlled with diet), oral group (DM controlled with oral medications), and insulin group (DM control required insulin).

RESULTS

Five of 541 (0.93%) HSED patients had type 1 DM, similar to 19/3246 (0.59%) controls (p = 0.375); 48 of 541 (8.88%) HSED patients had type 2 DM, similar to 287/3246 (8.84%) controls (p = 0.981). Using multinomial logistic regression analyses, the probability/risk of being in the severe ocular surface HSED group as opposed to the mild ocular surface HSED group were not statistically significantly different between DM patients and those without DM (p = 0.120; OR, 1.900; 95% CI, 0.846-4.266).

CONCLUSIONS

There may not be a positive association between type 2 DM and HSED.

摘要

目的

评估糖尿病（DM）与单纯疱疹性眼病（HSED）的发生和严重程度之间的关系。

方法

我们进行了两项子研究。纳入 2008 年 1 月至 2012 年 8 月在威尔斯眼科医院角膜科就诊的患者。研究 1 纳入了 541 例 HSED 患者和 3226 例对照者。研究 2 纳入了 40 例糖尿病和 120 例非糖尿病眼表 HSED 患者。根据最佳矫正视力（BCVA）将眼表 HSED 的严重程度分为轻度、中度或重度。如果患者的就诊次数少于 2 次或存在非单纯疱疹相关的威胁视力的疾病，则将其排除在外。糖尿病分为：饮食组（饮食控制的 DM）、口服组（口服药物控制的 DM）和胰岛素组（需要胰岛素控制的 DM）。

结果

541 例 HSED 患者中有 5 例（0.93%）患有 1 型糖尿病，与 3246 例对照者中的 19 例（0.59%）相似（p = 0.375）；541 例 HSED 患者中有 48 例（8.88%）患有 2 型糖尿病，与 3246 例对照者中的 287 例（8.84%）相似（p = 0.981）。使用多项逻辑回归分析，DM 患者与非 DM 患者相比，处于重度眼表 HSED 组的概率/风险无统计学显著差异（p = 0.120；OR，1.900；95%CI，0.846-4.266）。