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High prevalence of side population in human cancer cell lines.人癌细胞系中侧群细胞的高发生率。
Oncoscience. 2016 Apr 10;3(3-4):85-87. doi: 10.18632/oncoscience.300. eCollection 2016.
2
Cancer stem cell drugs target K-ras signaling in a stemness context.癌症干细胞药物在干性环境中靶向K-ras信号通路。
Oncogene. 2016 Oct 6;35(40):5248-5262. doi: 10.1038/onc.2016.59. Epub 2016 Mar 14.
3
Breast cancer stem cell selectivity of synthetic nanomolar-active salinomycin analogs.合成纳摩尔活性沙利霉素类似物对乳腺癌干细胞的选择性
BMC Cancer. 2016 Feb 23;16:145. doi: 10.1186/s12885-016-2142-3.
4
Drug Transporter-Mediated Protection of Cancer Stem Cells From Ionophore Antibiotics.药物转运体介导的癌症干细胞对离子载体抗生素的保护作用。
Stem Cells Transl Med. 2015 Sep;4(9):1028-32. doi: 10.5966/sctm.2015-0054. Epub 2015 Jul 1.
5
Geno- and cytotoxicity of salinomycin in human nasal mucosa and peripheral blood lymphocytes.沙利霉素对人鼻黏膜和外周血淋巴细胞的基因毒性和细胞毒性
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6
Salinomycin inhibits growth of pancreatic cancer and cancer cell migration by disruption of actin stress fiber integrity.沙利霉素通过破坏肌动蛋白应激纤维的完整性来抑制胰腺癌的生长和癌细胞迁移。
Cancer Lett. 2015 Mar 28;358(2):161-169. doi: 10.1016/j.canlet.2014.12.037. Epub 2014 Dec 18.
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Salinomycin exerts anticancer effects on human breast carcinoma MCF-7 cancer stem cells via modulation of Hedgehog signaling.沙利霉素通过调节 Hedgehog 信号通路对人乳腺癌 MCF-7 肿瘤干细胞发挥抗癌作用。
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Salinomycin inhibits the tumor growth of glioma stem cells by selectively suppressing glioma-initiating cells.沙利霉素通过选择性抑制胶质瘤起始细胞来抑制胶质瘤干细胞的肿瘤生长。
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The side population of ovarian cancer cells defines a heterogeneous compartment exhibiting stem cell characteristics.卵巢癌细胞的侧群定义了一个具有干细胞特征的异质性区室。
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离子载体抗生素作为癌症干细胞选择性药物：未解决的问题。

Ionophore Antibiotics as Cancer Stem Cell-Selective Drugs: Open Questions.

作者信息

Boesch Maximilian, Sopper Sieghart, Wolf Dominik

机构信息

Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland

Internal Medicine V, Medical University of Innsbruck, Innsbruck, Austria.

出版信息

Oncologist. 2016 Nov;21(11):1291-1293. doi: 10.1634/theoncologist.2016-0159. Epub 2016 Aug 2.

DOI:10.1634/theoncologist.2016-0159
PMID:27486200
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5189623/
Abstract

Ionophore antibiotics are promising compounds with potent anticancer and anti-cancer stem cell (anti-CSC) activity. However, resistance mediated by drug transporters potentially confines their use to CSC populations that do not exhibit appreciable drug efflux capacity. Further research is required to delineate which CSC subsets are likely to be susceptible to ionophore antibiotic cytotoxicity.

摘要

离子载体抗生素是具有强大抗癌和抗癌干细胞（抗CSC）活性的有前景的化合物。然而，由药物转运蛋白介导的耐药性可能会限制它们仅用于那些没有明显药物外排能力的CSC群体。需要进一步研究来确定哪些CSC亚群可能对离子载体抗生素的细胞毒性敏感。