Dronova O M, Makarova G V
Radiobiol Radiother (Berl). 1989;30(2):137-41.
In radiotherapy of patients with prostate carcinoma the microflora of the intestine and its dynamics were studied. The mostly older patients with chronic affections of the digestive tract showed a considerable injury in composition of intestinal microflora. The radioeffects on regions of minor pelvis are accompanied by acute radioreactions and a chronic radiogenic intestinal syndrome that deteriorates the existing disorders of quantitative and qualitative composition of intestinal microflora considerably what, on its part, contributes to maintenance of the pathological process in intestine. In addition to therapeutic remedies to suppress radioreactions on intestine therefore it is appropriate to apply preparations that affect the composition of intestinal microflora in a normalizing manner.
在前列腺癌患者的放射治疗中,对肠道微生物群及其动态变化进行了研究。大多数患有消化道慢性疾病的老年患者肠道微生物群的组成受到了相当大的损害。对小骨盆区域的放射效应伴随着急性放射反应和慢性放射性肠道综合征,这大大恶化了肠道微生物群数量和质量组成的现有紊乱,而这反过来又有助于维持肠道中的病理过程。因此,除了使用治疗药物来抑制肠道的放射反应外,还适宜应用能以正常化方式影响肠道微生物群组成的制剂。