Velaga Swetha B, Nittala Muneeswar G, Parinitha B, Sadda S R, Chhablani Jay Kumar
Department of Ophthalmology, Doheny Eye Institute, University of Southern California, Los Angeles, California, USA.
Smt. Kanuri Santhamma Retina Vitreous Centre, L. V. Prasad Eye Institute, Hyderabad, Telangana, India.
Indian J Ophthalmol. 2016 Jun;64(6):452-8. doi: 10.4103/0301-4738.187675.
To evaluate the correlation between retinal sensitivity and cystoid space characteristics in eyes with diabetic macular edema (DME).
Prospective cross-sectional study of 22 subjects with DME (32 treatment-naïve eyes). All study subjects underwent complete ophthalmic examination, including slit-lamp biomicroscopy and dilated fundus examination. All subjects underwent spectral domain optical coherence tomography (SD-OCT) and microperimetry (MP). Intraretinal cystoid space (ICS) volume was generated after manual delineation of cystoid space boundaries using the three-dimensional-OCT software. Various SD-OCT parameters, including retinal thickness, retinal volume, cystoid space volume, cystoid space intensity, and outer retinal structure integrity, were correlated with MP parameters and best-corrected visual acuity (BCVA).
Subject's mean age was 57 ± 9 years. The mean logarithm of minimum angle of resolution BCVA was 0.4 ± 0.2. The intraclass correlation coefficient for inter- and intra-grader assessment of cystoid space volume by manual delineation was 0.99 and 0.99, respectively. Mean total ICS volume was 0.4 ± 0.4 mm 3 and for the foveal center, subfield was 0.1 ± 0.1 mm 3 . Mean retinal sensitivity was 12.89 ± 10 dB; however, foveal retinal sensitivity was 12.3 ± 11.1 dB. We found no significant correlation between BCVA and total cystoid space volume (r = 0.33, P = 0.06). Correlation between total retinal sensitivity and total ICS was negative and nonsignificant (r = -0.17, P = 0.36). Correlation between foveal retinal sensitivity and foveal cystoid space intensity was moderate and marginally significant (r = -0.43, P = 0.05).
Total cystoid space volume was not significantly correlated with BCVA or total retinal sensitivity in subjects with DME. Foveal cystoid space optical intensity was negatively correlated with foveal retinal sensitivity. These findings suggest further investigation of cystoid space characteristics in the setting of DME may be of value.
评估糖尿病性黄斑水肿（DME）患者视网膜敏感度与囊样间隙特征之间的相关性。
对22例DME患者（32只初治眼）进行前瞻性横断面研究。所有研究对象均接受了全面的眼科检查，包括裂隙灯生物显微镜检查和散瞳眼底检查。所有对象均接受了光谱域光学相干断层扫描（SD-OCT）和微视野计（MP）检查。使用三维OCT软件手动划定囊样间隙边界后生成视网膜内囊样间隙（ICS）体积。将包括视网膜厚度、视网膜体积、囊样间隙体积、囊样间隙强度和外层视网膜结构完整性在内的各种SD-OCT参数与MP参数及最佳矫正视力（BCVA）进行相关性分析。
研究对象的平均年龄为57±9岁。最佳矫正视力的最小分辨角对数平均值为0.4±0.2。通过手动划定对囊样间隙体积进行分级者间和分级者内评估的组内相关系数分别为0.99和0.99。平均总ICS体积为0.4±0.4mm³，黄斑中心子区域为0.1±0.1mm³。平均视网膜敏感度为12.89±10dB；然而，黄斑视网膜敏感度为12.3±11.1dB。我们发现BCVA与总囊样间隙体积之间无显著相关性（r = 0.33，P = 0.06）。总视网膜敏感度与总ICS之间的相关性为负且无统计学意义（r = -0.17，P = 0.36）。黄斑视网膜敏感度与黄斑囊样间隙强度之间的相关性为中度且边缘显著（r = -0.43，P = 0.05）。
DME患者的总囊样间隙体积与BCVA或总视网膜敏感度无显著相关性。黄斑囊样间隙光学强度与黄斑视网膜敏感度呈负相关。这些发现表明，在DME背景下进一步研究囊样间隙特征可能具有价值。
