Nair Akshay Gopinathan, Jain Vandana, Gopinathan Indumati, Murthy Anuradha
Ophthalmic Plastic Surgery and Ocular Oncology Services, Advanced Eye Hospital and Institute, Navi Mumbai, Maharashtra, India.
Clinico Path Labs, Mumbai, Maharashtra, India.
Indian J Ophthalmol. 2016 Jun;64(6):466-8. doi: 10.4103/0301-4738.187680.
We describe the clinicopathological features of a solid variant of orbital angioleiomyoma. A review of clinical records, diagnostic, and radiographic studies combined with histopathological evaluation with standard histochemical staining and immunohistochemistry was conducted. A 22-year-old male patient presented with a mass in the region of the left lacrimal gland that was gradually increasing over the past 2 years. Radiological and clinical examinations showed no signs suspicious of a malignancy and fine needle aspiration cytology was inconclusive. Therefore, an excision biopsy was performed. On histopathological examination, the picture was consistent with a benign spindle cell tumor. Immunohistochemistry showed positivity for CD 34 and CD 31 (markers for vascular endothelium). The tumor also showed positivity for smooth muscle actin and Ki-67 proliferative index was low. Angioleiomyomas are rarely encountered in the orbit and has features seen in leiomyoma as well as some vascular tumor elements. In most cases, surgical excision is usually curative.
我们描述了眼眶血管平滑肌瘤实性变体的临床病理特征。我们对临床记录、诊断和影像学研究进行了回顾,并结合标准组织化学染色和免疫组织化学进行组织病理学评估。一名22岁男性患者,左泪腺区域出现肿物,在过去2年中逐渐增大。放射学和临床检查未发现可疑恶性征象,细针穿刺细胞学检查结果不明确。因此,进行了切除活检。组织病理学检查显示,病变符合良性梭形细胞瘤。免疫组织化学显示CD 34和CD 31(血管内皮标志物)呈阳性。肿瘤平滑肌肌动蛋白也呈阳性,Ki-67增殖指数较低。血管平滑肌瘤在眼眶中很少见,具有平滑肌瘤以及一些血管肿瘤成分的特征。在大多数情况下,手术切除通常可治愈。