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为糖尿病和高血糖合并妊娠开发的耻骨联合-宫底高度图表的验证:一项观察性研究。

Validation of a symphysis-fundal height chart developed for pregnancy complicated by diabetes and hyperglycemia: an observational study.

作者信息

de Sousa Basso Neusa Aparecida, Morceli Glilciane, Costa Roberto, Dias Adriano, Rudge Marilza Vieira Cunha, Calderon Iracema Mattos Paranhos

机构信息

Graduate Program in Gynecology, Obstetrics and Mastology, Botucatu Medical School, UNESP, Botucatu, Brazil.

Dr. Raul Bauab-Jahu Education Foundation, Jau, Brazil.

出版信息

Reprod Health. 2016 Aug 3;13(1):89. doi: 10.1186/s12978-016-0202-4.

Abstract

BACKGROUND

The present study validates a symphysis-fundal height chart (SFH-chart) for pregnant women with type 2 diabetes mellitus (DM2), gestational diabetes mellitus (GDM) and mild gestational hyperglycemia (MGH) attending at the Diabetes and Pregnancy Reference Service of the Botucatu Medical School, UNESP, Brazil.

METHODS

A cross-sectional study was carried out to evaluate the performance of the specific FHC in predicting small (SGA) and large (LGA) for gestational age newborns (NB). We evaluated 206 pregnant women with DM2, GDM or MGH and their NB. The last symphysis-fundal height measure, taken at birth, was used to determine the sensitivity index (Sens), specificity index (Spe), positive prediction value (PPV), negative prediction value (NPV) and accuracy in predicting SGA and LGA. The gold standard was the Lubchenco birth weight/gestational age ratio evaluated at birth.

RESULTS

The mothers showed adequate glycemic control; 91.3 % of all pregnant women achieved HbA1c < 6,5 % in the third trimester. The SFH-chart tested achieved 100 % of Sens and NPV in predicting both SGA and LGA, with accuracy of 90.3 % (85.5; 93.6) and 91.8 % (87.2; 94.8), respectively, for predicting SGA and LGA newborns.

CONCLUSIONS

The Basso SFH-chart showed high performance in predicting both SGA and LGA newborns of DM-2, GDM and MGH mothers, with better performance than the national reference SFH-chart. These findings support the internal validation of the Basso SFH-chart, which may be implemented in the prenatal care of the Diabetes and Pregnancy Reference Service-Botucatu Medical School/UNESP.

摘要

背景

本研究验证了一种耻骨联合-宫底高度图表(SFH图表),该图表适用于在巴西圣保罗州立大学博图卡图医学院糖尿病与妊娠参考服务中心就诊的2型糖尿病(DM2)、妊娠期糖尿病(GDM)和轻度妊娠高血糖(MGH)孕妇。

方法

开展了一项横断面研究,以评估特定耻骨联合-宫底高度(FHC)在预测小于胎龄儿(SGA)和大于胎龄儿(LGA)方面的性能。我们评估了206例患有DM2、GDM或MGH的孕妇及其新生儿。出生时测量的最后一次耻骨联合-宫底高度用于确定预测SGA和LGA的敏感性指数(Sens)、特异性指数(Spe)、阳性预测值(PPV)、阴性预测值(NPV)和准确性。金标准是出生时评估的卢申科出生体重/孕周比值。

结果

母亲们血糖控制良好;所有孕妇中91.3%在孕晚期糖化血红蛋白(HbA1c)<6.5%。所测试的SFH图表在预测SGA和LGA方面的敏感性和NPV均达到100%,预测SGA和LGA新生儿的准确性分别为90.3%(85.5;93.6)和91.8%(87.2;94.8)。

结论

Basso SFH图表在预测DM-2、GDM和MGH母亲的SGA和LGA新生儿方面表现出色,性能优于国家参考SFH图表。这些发现支持对Basso SFH图表进行内部验证,该图表可在糖尿病与妊娠参考服务中心-博图卡图医学院/圣保罗州立大学的产前护理中实施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd8f/4973029/3390211eaece/12978_2016_202_Fig1_HTML.jpg

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