研究钴（III）-三唑体系作为缺氧激活药物递送的原型。
Investigation of cobalt(iii)-triazole systems as prototypes for hypoxia-activated drug delivery.
作者信息
de Souza Isabela Cristina Aguiar, Faro Leticia Villafranca, Pinheiro Carlos Basilio, Gonzaga Daniel Tadeu Gomes, da Silva Fernando de Carvalho, Ferreira Vitor Francisco, Miranda Fabio da Silva, Scarpellini Marciela, Lanznaster Mauricio
机构信息
Universidade Federal Fluminense, Instituto de Química, Outeiro S. João Batista S/N, 24020-141, Niterói, RJ, Brazil.
出版信息
Dalton Trans. 2016 Sep 21;45(35):13671-4. doi: 10.1039/c6dt02456d. Epub 2016 Aug 4.
Three novel cobalt(iii)-triazole complexes with structural and redox properties suitable for hypoxia-activated drug delivery were obtained. A major influence of the ancillary ligands (TPA, py2en, py2enMe2) on the electronic properties and reactivity of their complexes was observed. An [O2]-dependent reduction to cobalt(ii) by ascorbic acid provided evidence of hypoxic selectivity.
获得了三种具有适合缺氧激活药物递送的结构和氧化还原性质的新型钴（III）-三唑配合物。观察到辅助配体（TPA、py2en、py2enMe2）对其配合物的电子性质和反应性有重大影响。抗坏血酸将其还原为钴（II）的过程呈现出对氧的依赖性，这为缺氧选择性提供了证据。
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