FOXD3 controls pluripotency through modulating enhancer activity.
作者信息
Yong Jay-Sze, Intriago-Baldeón Dámaris P, Lam Eric W-F
机构信息
Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London, UK.
出版信息
Stem Cell Investig. 2016 May 27;3:17. doi: 10.21037/sci.2016.05.03. eCollection 2016.
Abstract
摘要
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The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression.胚胎干细胞转录因子Oct-4和FoxD3相互作用以调节内胚层特异性启动子的表达。
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Foxd3 Promotes Exit from Naive Pluripotency through Enhancer Decommissioning and Inhibits Germline Specification.Foxd3通过增强子停用促进从原始多能性退出，并抑制生殖系特化。
Cell Stem Cell. 2016 Jan 7;18(1):118-33. doi: 10.1016/j.stem.2015.09.010.
2
FOXD3 Regulates Pluripotent Stem Cell Potential by Simultaneously Initiating and Repressing Enhancer Activity.FOXD3通过同时启动和抑制增强子活性来调控多能干细胞的潜能。
Cell Stem Cell. 2016 Jan 7;18(1):104-17. doi: 10.1016/j.stem.2015.10.003.
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Foxd3: A Repressor, an Activator, or Both?Foxd3：是抑制因子，还是激活因子，还是两者兼具？
Cell Stem Cell. 2016 Jan 7;18(1):1-2. doi: 10.1016/j.stem.2015.12.009.
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FOXD3 suppresses tumor growth and angiogenesis in non-small cell lung cancer.FOXD3抑制非小细胞肺癌的肿瘤生长和血管生成。
Biochem Biophys Res Commun. 2015 Oct 9;466(1):111-6. doi: 10.1016/j.bbrc.2015.08.116. Epub 2015 Sep 2.
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Hypermethylation of FOXD3 suppresses cell proliferation, invasion and metastasis in hepatocellular carcinoma.FOXD3的高甲基化抑制肝细胞癌的细胞增殖、侵袭和转移。
Exp Mol Pathol. 2015 Oct;99(2):374-82. doi: 10.1016/j.yexmp.2015.06.017. Epub 2015 Jun 22.
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Epigenetic priming of enhancers predicts developmental competence of hESC-derived endodermal lineage intermediates.增强子的表观遗传预激发可预测人胚胎干细胞来源的内胚层谱系中间体的发育潜能。
Cell Stem Cell. 2015 Apr 2;16(4):386-99. doi: 10.1016/j.stem.2015.02.013.
7
Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice.先驱因子在干细胞可塑性和谱系选择中调控超级增强子动力学。
Nature. 2015 May 21;521(7552):366-70. doi: 10.1038/nature14289. Epub 2015 Mar 18.
8
Foxd3 suppresses NFAT-mediated differentiation to maintain self-renewal of embryonic stem cells.Foxd3抑制NFAT介导的分化以维持胚胎干细胞的自我更新。
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Biochem Biophys Res Commun. 2014 Apr 4;446(2):580-4. doi: 10.1016/j.bbrc.2014.03.019. Epub 2014 Mar 12.
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