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发作性睡病的全球视野——一项综述研究

A Global View on Narcolepsy - A Review Study.

作者信息

Klimova Blanka, Maresova Petra, Novotny Michal, Kuca Kamil

机构信息

Faculty of Informatics and Management, University of Hradec Kralove, Hradec Kralove, Czech Republic.

Department of Neurology and Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.

出版信息

Mini Rev Med Chem. 2018 Feb 14;18(5):458-464. doi: 10.2174/1389557516666160801095630.

Abstract

Narcolepsy is an incurable neurological disorder when the brain is not able to regulate a sleep and wakefulness cycle correctly. The affected person suddenly falls asleep during the day or he/she suffers from excessive day sleepiness. In addition, people may also suffer from cataplexy, hypnagogic hallucinations, sleep paralysis, and disturbed nighttime sleep. The purpose of this review study is to provide the latest information on both clinical and socioeconomic issues in the field of narcolepsy treatment and emphasize its benefits and limitations. The methodological approaches include a method of literature review of available sources exploring the issue of narcolepsy, both from a global and specific perspective point of view. On the basis of evaluation of these literature sources, the researched issue is examined. The main benefits (e.g., new drugs are being tested or non-invasive cognitive behavioral therapies are being applied) and limitations (e.g., late diagnosis of the disease or lifelong and costly treatment) of the treatment of narcolepsy are highlighted. The findings call for more research in the field of the development of novel drugs reflecting understanding of the neurological basis of narcolepsy and early diagnosis in order to eliminate the symptoms of narcolepsy and prevent the development of this disease.

摘要

发作性睡病是一种无法治愈的神经紊乱疾病,此时大脑无法正确调节睡眠和清醒周期。患者会在白天突然入睡,或遭受过度日间嗜睡的困扰。此外,患者还可能出现猝倒、入睡前幻觉、睡眠瘫痪以及夜间睡眠障碍。本综述研究的目的是提供发作性睡病治疗领域临床和社会经济问题的最新信息,并强调其益处和局限性。方法包括从全球和特定视角对探讨发作性睡病问题的现有文献进行综述的方法。在对这些文献来源进行评估的基础上,对研究问题进行考察。突出了发作性睡病治疗的主要益处(如正在测试新药或应用非侵入性认知行为疗法)和局限性(如疾病诊断延迟或终身且昂贵的治疗)。研究结果呼吁在反映对发作性睡病神经学基础理解的新型药物研发和早期诊断领域开展更多研究,以消除发作性睡病症状并预防该疾病的发展。

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