麦角酸二乙酰胺（LSD）及其他相关致幻剂会引发豚鼠的肌阵挛性跳跃行为。

LSD and other related hallucinogens elicit myoclonic jumping behavior in the guinea pig.

Carvey P, Nausieda P, Weertz R, Klawans H

Dept. of Neurological Sciences, Rush Presbyterian St. Lukes Medical Center, Chicago, IL.

Prog Neuropsychopharmacol Biol Psychiatry. 1989;13(1-2):199-210. doi: 10.1016/0278-5846(89)90017-1.

Abstract

We evaluated the behavioral response of guinea pigs to hallucinogenic agents in order to characterize the response of this species to a variety of known hallucinogenic drugs. 2. The systemic injection of LSD in the guinea pig elicited a "myoclonic-like" response the frequency of which was dose-dependent. This behavior exhibited rapid tolerance which was more prominent at higher doses. 3. Subacute mescaline pretreatment reduced the myoclonic response to LSD suggesting cross-tolerance. 4. Mescaline, DOM, TMA, DMA and 5 Me-ODMT also elicited myoclonus in a dose-dependent manner and in potency ratios which approximate the human experience for hallucinogenic activity. 5. Brom-LSD failed to induce myoclonus. 6. Since the myoclonic response of the guinea pig shares a number of pharmacologic characteristics with the human hallucinogenic event, this species may be useful in the study of hallucinogenic compounds.

摘要

我们评估了豚鼠对致幻剂的行为反应，以便描述该物种对多种已知致幻药物的反应特征。2. 给豚鼠全身注射麦角酸二乙酰胺（LSD）引发了一种“类肌阵挛”反应，其频率呈剂量依赖性。这种行为表现出快速耐受性，在较高剂量时更为明显。3. 亚急性三甲氧苯乙胺预处理降低了对LSD的肌阵挛反应，提示存在交叉耐受性。4. 三甲氧苯乙胺、2,5-二甲氧基-4-甲基苯丙胺（DOM）、三甲胺基苯乙胺（TMA）、二甲基色胺（DMA）和5-甲氧基-N,N-二甲基色胺（5 Me-ODMT）也以剂量依赖性方式引发肌阵挛，其效价比近似于人类致幻活性体验。5. 溴-LSD未能诱发肌阵挛。6. 由于豚鼠的肌阵挛反应与人类致幻事件具有许多药理学特征，该物种可能在致幻化合物研究中有用。