Murdoch W J
Department of Animal Science, University of Wyoming, Laramie 82071.
Prostaglandins. 1989 Mar;37(3):331-4. doi: 10.1016/0090-6980(89)90003-8.
The antiinflammatory steroid, prednisolone, was administered to sheep during the preovulatory period. The drug did not produce a blockade of follicular rupture. However, prednisolone negated a rise in production of prostaglandin (PG) F2 alpha characteristic of preovulatory follicles. Indomethacin, a nonsteroidal antiinflammatory agent, was 100% effective in preventing ovulation. Levels of PGF2 alpha within follicular tissue were very low following treatment with indomethacin. These findings indicate that ovulation can occur in the absence of a preovulatory elevation in follicular accumulation of PGF2 alpha. Potency of antiinflammatory drugs as inhibitors of ovulation appears to hinge upon their ability to cause a marked suppression in follicular synthesis of prostaglandins.
在排卵前期给绵羊施用抗炎类固醇泼尼松龙。该药物未导致卵泡破裂受阻。然而，泼尼松龙消除了排卵前卵泡特征性的前列腺素（PG）F2α产量的升高。非甾体抗炎药吲哚美辛在预防排卵方面100%有效。用吲哚美辛治疗后，卵泡组织内的PGF2α水平非常低。这些发现表明，在卵泡PGF2α蓄积没有排卵前升高的情况下也可发生排卵。抗炎药物作为排卵抑制剂的效力似乎取决于它们引起卵泡前列腺素合成显著抑制的能力。
