Hafermann Matthew J, Barber Gerard R, Dreskin Stephen C, Lindberg Gordon K
University of Washington Medical Center, Seattle, WA, USA.
Department of Pharmacy Services, University of Colorado Hospital, Aurora, CO, USA; School of Pharmacy, University of Colorado, Aurora, CO, USA.
SAGE Open Med Case Rep. 2014 Apr 17;2:2050313X14532250. doi: 10.1177/2050313X14532250. eCollection 2014.
To describe a case of toxic epidermal necrolysis likely caused by cephalexin with a review of the literature.
An 80-year-old male with a known allergy to cephalosporins, residing at a long-term acute care hospital, received cephalexin for a urinary tract infection. And 1 day after starting therapy, the patient developed an extensive erythematous rash accompanied by skin sloughing; 4 days after receiving cephalexin, the patient was directly admitted to the burn intensive care unit and was diagnosed with toxic epidermal necrolysis involving 56% of the total body surface area. Progressive deterioration to multisystem organ failure ensued, and the patient died 5 days following his admission to the burn intensive care unit. At the time of death, ulcerations were noted over approximately 80% of his body.
The temporal association of the patient's ingestion of cephalexin for a urinary tract infection to his onset of toxic epidermal necrolysis suggests that this 80-year-old man developed toxic epidermal necrolysis following the administration of cephalexin for a urinary tract infection.
描述一例可能由头孢氨苄引起的中毒性表皮坏死松解症病例，并对相关文献进行综述。
一名80岁男性，已知对头孢菌素过敏，居住在一家长期急性护理医院，因尿路感染接受头孢氨苄治疗。开始治疗1天后，患者出现广泛的红斑疹并伴有皮肤脱落；接受头孢氨苄4天后，患者被直接收入烧伤重症监护病房，被诊断为中毒性表皮坏死松解症，累及全身表面积的56%。随后病情逐渐恶化为多系统器官衰竭，患者在入住烧伤重症监护病房5天后死亡。死亡时，其身体约80%出现溃疡。
患者因尿路感染服用头孢氨苄后出现中毒性表皮坏死松解症，这一时间关联表明，这名80岁男性在因尿路感染服用头孢氨苄后患上了中毒性表皮坏死松解症。
