Gardani G, Valvo F, Lattuada A
Istituto di Scienze Radiologiche, Università, Milano.
Radiol Med. 1989 May;77(5):524-9.
Three-hundred and sixty-six patients affected with seminoma testis (234 stage I, 85 stage II low, 47 advanced diseases) were treated between January 1968 and December 1985. Overall incidence of anaplastic lesions (43 patients) was 12%, progressively increasing with stage of the disease (9% stage I, 13% stage II low, 21% advanced disease). Only 343 patients submitted to exclusive curative/prophylactic radiotherapy were studied: 35 of them were anaplastic (22 stage I, 11 stage II low, 2 advanced disease). Radiation therapy was always performed regardless of the histologic subtype. Recurrences occurred in 14% of anaplastic tumors (5/35) and in 7.5% of classical seminomas (23/308). There was no statistically-significant difference between global and stage-by-stage failures. After literature review and complete analysis of the patterns of recurrence, the authors stress the lack of evidence suggesting a different radioresponsiveness of anaplastic versus classical seminomas; nonetheless, a more accurate staging is recommended for anaplastic variants, since they tend to appear in the advanced stages of the disease.
1968年1月至1985年12月期间，对366例睾丸精原细胞瘤患者（234例I期、85例II期低危、47例晚期）进行了治疗。间变病变的总体发生率（43例患者）为12%，并随疾病分期逐渐增加（I期为9%，II期低危为13%，晚期为21%）。仅对343例接受单纯根治性/预防性放疗的患者进行了研究：其中35例为间变（22例I期、11例II期低危、2例晚期）。无论组织学亚型如何，均进行放射治疗。间变肿瘤的复发率为14%（5/35），经典精原细胞瘤的复发率为7.5%（23/308）。总体复发率与分期复发率之间无统计学显著差异。在查阅文献并对复发模式进行全面分析后，作者强调缺乏证据表明间变精原细胞瘤与经典精原细胞瘤的放射反应性不同；尽管如此，对于间变亚型，建议进行更准确的分期，因为它们往往出现在疾病的晚期阶段。
