Signorelli Maria S, Concerto Carmen, Battaglia Eliana, Costanzo Maria C, Battaglia Fortunato, Aguglia Eugenio
Psychiatry Unit, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Psychiatry Unit, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy; Department of Interprofessional Health Sciences and Health Administration, Seton Hall University, South Orange, NJ, USA.
SAGE Open Med Case Rep. 2014 Dec 4;2:2050313X14561778. doi: 10.1177/2050313X14561778. eCollection 2014.
Obsessive-compulsive disorder is a chronic and disabling condition that often proves to be treatment resistant. Of the patients suffering from obsessive-compulsive disorder, 10%-27% may attempt suicide at least once in their life. We report the case of a patient who presented severe obsessive-compulsive disorder symptoms and attempted suicide ingesting 25 tablets of fluoxetine (20 mg). The patient was treated with venlafaxine and agomelatine and showed improvement of obsessive symptoms and suicidal ideation. Future studies are needed to investigate this treatment regime in large cohorts of obsessive-compulsive disorder patients with suicidal ideation.
强迫症是一种慢性致残性疾病，往往难以治疗。在患有强迫症的患者中，10% - 27%的人一生中可能至少尝试过一次自杀。我们报告了一例患者，该患者出现严重的强迫症症状，并吞服25片氟西汀（20毫克）企图自杀。该患者接受了文拉法辛和阿戈美拉汀治疗，强迫症状和自杀观念有所改善。未来需要开展研究，在大量有自杀观念的强迫症患者队列中调查这种治疗方案。
