Concerto Carmen, Rodolico Alessandro, Meo Valeria, Chiappetta Donatella, Bonelli Marina, Mineo Ludovico, Saitta Giulia, Stuto Sebastiano, Signorelli Maria Salvina, Petralia Antonino, Lanza Giuseppe, Aguglia Eugenio
Psychiatry Unit, Department of Clinical and Experimental Medicine, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy.
Department of Surgery and Medical-Surgical Specialties, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy.
Curr Issues Mol Biol. 2022 Jul 25;44(8):3335-3350. doi: 10.3390/cimb44080230.
Sexual dysfunctions are common side effects reported by patients during antidepressant treatment. When they occur, patients often discontinue psychopharmacological therapy, with a negative impact on the underlying psychiatric disease. Recently, great attention has been paid to the use of nutraceuticals in the management of psychiatric disorders, although a systematic review on their effects as a treatment option for antidepressant-induced sexual dysfunctions (AISD) is lacking. Here, we conducted a systematic search in the following databases: MEDLINE (through PubMed), EMBASE, PsycINFO, Cochrane Central Register of Controlled Trials, and Web of Science. We searched eligible studies among parallel or crossover randomized controlled trials (RCTs) in adult populations. After this process, a total of 10 articles that evaluated the effect of six different nutraceuticals versus placebo were included: Maca Root, S-adenosyl-L-methionine (SAMe), Rosa Damascena, Ginkgo Biloba, Saffron, and Yohimbine. Overall, a high dose of Maca Root and the use of SAMe or Saffron may improve AISD. Additionally, the administration of Rosa Damascena seemed to be more effective in men than in women, whereas no evidence of effects emerged for Gingko Biloba and Yohimbine. Given the mixed results still available, future RCTs should consider larger samples and confounding factors, such as depressive status and individual vulnerability.
性功能障碍是患者在抗抑郁治疗期间报告的常见副作用。当这些副作用出现时，患者往往会停止心理药物治疗，这对潜在的精神疾病产生负面影响。最近，营养保健品在精神疾病管理中的应用受到了极大关注，尽管缺乏关于其作为抗抑郁药引起的性功能障碍（AISD）治疗选择效果的系统评价。在此，我们在以下数据库中进行了系统检索：MEDLINE（通过PubMed）、EMBASE、PsycINFO、Cochrane对照试验中央注册库和科学网。我们在成人人群的平行或交叉随机对照试验（RCT）中检索符合条件的研究。经过这一过程，共纳入了10篇评估六种不同营养保健品与安慰剂效果对比的文章：玛卡根、S-腺苷-L-蛋氨酸（SAMe）、大马士革玫瑰、银杏、藏红花和育亨宾。总体而言，高剂量的玛卡根以及使用SAMe或藏红花可能改善AISD。此外，大马士革玫瑰的给药对男性似乎比女性更有效，而银杏和育亨宾则没有效果证据。鉴于现有结果参差不齐，未来的RCT应考虑更大的样本量和混杂因素，如抑郁状态和个体易感性。
