一名真性红细胞增多症患者在辛伐他汀和阿仑膦酸盐联合治疗期间出现的显著血液学和分子反应模式。
A remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination therapy with simvastatin and alendronate.
作者信息
Sørensen Anders Lindholm, Kallenbach Klaus, Hasselbalch Hans Carl
机构信息
Department of Hematology, Zealand University Hospital, Denmark; Institute for Inflammation Research, Center for Rheumatology and Spine Diseases, Rigshospitalet Copenhagen University Hospital, Denmark.
Department of Pathology, Zealand University Hospital, Denmark.
出版信息
Leuk Res Rep. 2016 Jun 27;6:20-3. doi: 10.1016/j.lrr.2016.06.004. eCollection 2016.
We report a 57-year old man with polycythemia vera, who had a remarkable hematological and molecular response during treatment with simvastatin and alendronate. The patient was treated with this combination for 56 months, and during this period the patient has been in complete hematological remission. The JAK2-V617F allele burden has dropped from 64% to sustained values below 20%, and follow-up bone marrow biopsies have revealed no change in PV features, without any regular cytoreductive treatment.
我们报告了一名57岁的真性红细胞增多症男性患者，其在接受辛伐他汀和阿仑膦酸盐治疗期间出现了显著的血液学和分子反应。该患者接受这种联合治疗56个月，在此期间患者一直处于完全血液学缓解状态。JAK2-V617F等位基因负荷已从64%降至持续低于20%的值，后续骨髓活检显示真性红细胞增多症特征无变化，且未进行任何常规的细胞减灭治疗。
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