扩展球状胶质tau亚型的表型关联。
Expanding the phenotypic associations of globular glial tau subtypes.
作者信息
Burrell James R, Forrest Shelley, Bak Thomas H, Hodges John R, Halliday Glenda M, Kril Jillian J
机构信息
Neuroscience Research Australia, Sydney, Australia; University of New South Wales, Sydney, Australia.
Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, Australia.
出版信息
Alzheimers Dement (Amst). 2016 Apr 8;4:6-13. doi: 10.1016/j.dadm.2016.03.006. eCollection 2016.
INTRODUCTION
Clinicopathologic correlation in non-Alzheimer's tauopathies is variable, despite refinement of pathologic diagnostic criteria. In the present study, the clinical and neuroimaging characteristics of globular glial tauopathy (GGT) were examined to determine whether subtyping according to consensus guidelines improves clinicopathologic correlation.
METHODS
Confirmed GGT cases (n = 11) were identified from 181 frontotemporal tauopathy cases. Clinical and neuroimaging details were collected, and cases sub-typed according to the consensus criteria for GGT diagnosis. Relationships between clinical syndrome and GGT subtype were investigated.
RESULTS
In total, 11 patients (seven males, four females, mean age = 67.3 +/- 10.6 years) with GGT were included. Most, but not all, presented with behavioral variant frontotemporal dementia, but none had amyotrophic lateral sclerosis. Subtyping of GGT proved to be difficult and did not improve clinicopathologic correlation.
DISCUSSION
Sub-classification of GGT pathology may be difficult and did not improve clinicopathologic correlation. Better biomarkers of tau pathology are needed.
引言
尽管病理诊断标准有所完善，但非阿尔茨海默病性tau蛋白病的临床病理相关性仍存在差异。在本研究中，对球状胶质tau蛋白病（GGT）的临床和神经影像学特征进行了检查，以确定根据共识指南进行亚型分类是否能改善临床病理相关性。
方法
从181例额颞叶tau蛋白病病例中确定确诊的GGT病例（n = 11）。收集临床和神经影像学细节，并根据GGT诊断的共识标准对病例进行亚型分类。研究临床综合征与GGT亚型之间的关系。
结果
总共纳入了11例GGT患者（7例男性，4例女性，平均年龄 = 67.3 +/- 10.6岁）。大多数（但并非全部）表现为行为变异型额颞叶痴呆，但均无肌萎缩侧索硬化。事实证明，GGT的亚型分类很困难，且并未改善临床病理相关性。
讨论
GGT病理的亚分类可能很困难，且并未改善临床病理相关性。需要更好的tau蛋白病理生物标志物。
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