Mansur Rodrigo B, Cunha Graccielle R, Asevedo Elson, Zugman André, Zeni-Graiff Maiara, Rios Adiel C, Sethi Sumit, Maurya Pawan K, Levandowski Mateus L, Gadelha Ary, Pan Pedro M, Stertz Laura, Belangero Síntia I, Kauer-Sant' Anna Márcia, Teixeira Antônio L, Mari Jair J, Rohde Luis A, Miguel Euripedes C, McIntyre Roger S, Grassi-Oliveira Rodrigo, Bressan Rodrigo A, Brietzke Elisa
National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, São Paulo, Brazil.
Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, Brazil.
PLoS One. 2016 Aug 4;11(8):e0160455. doi: 10.1371/journal.pone.0160455. eCollection 2016.
Socioeconomic disadvantage (SED) has been consistently associated with early life mental health problems. SED has been shown to impact multiple biological systems, including the regulation of neurotrophic proteins, immune-inflammatory and oxidative stress markers, which, conversely, have been reported to be relevant to physiological and pathological neurodevelopment This study investigated the relationship between SED, different domains of psychopathology, serum levels of interleukin-6 (IL6), thiobarbituric acid-reactive substance (TBARS) and brain-derived neurotrophic factor (BDNF). We hypothesized that a composite of socioeconomic risk would be associated with psychopathology and altered levels of peripheral biomarkers. In addition, we hypothesized that SED would moderate the associations between mental health problems, IL6, TBARS and BDNF.
Using a cross-sectional design, we measured the serum levels of IL6, TBARS and BDNF in 495 children aged 6 to 12. We also investigated socio-demographic characteristics and mental health problems using the Child Behaviour Checklist (CBCL) DSM-oriented scales. SED was evaluated using a cumulative risk model. Generalized linear models were used to assess associations between SED, biomarkers levels and psychopathology. SED was significantly associated with serum levels of IL6 (RR = 1.026, 95% CI 1.004; 1.049, p = 0.020) and TBARS (RR = 1.077, 95% CI 1.028; 1.127, p = 0.002). The association between SED and BDNF was not statistically significant (RR = 1.031, 95% CI 0.997; 1.066, p = 0.077). SED was also significantly associated with all CBCL DSM-oriented scales (all p < 0.05), whereas serum biomarkers (i.e. IL6, TBARS, BDNF) were associated with specific subscales. Moreover, the associations between serum biomarkers and domains of psychopathology were moderated by SED, with stronger correlations between mental health problems, IL6, TBARS, and BDNF being observed in children with high SED.
In children, SED is highly associated with mental health problems. Our findings suggest that this association may be moderated via effects on multiple interacting neurobiological systems.
社会经济劣势（SED）一直与儿童期心理健康问题相关。SED已被证明会影响多个生物系统，包括神经营养蛋白的调节、免疫炎症和氧化应激标志物，而这些反过来又被报道与生理和病理神经发育相关。本研究调查了SED、精神病理学不同领域、血清白细胞介素-6（IL6）、硫代巴比妥酸反应物质（TBARS）和脑源性神经营养因子（BDNF）水平之间的关系。我们假设社会经济风险综合因素将与精神病理学及外周生物标志物水平改变相关。此外，我们假设SED将调节心理健康问题、IL6、TBARS和BDNF之间的关联。
采用横断面设计，我们测量了495名6至12岁儿童的血清IL6、TBARS和BDNF水平。我们还使用儿童行为检查表（CBCL）中面向DSM的量表调查了社会人口学特征和心理健康问题。SED采用累积风险模型进行评估。使用广义线性模型评估SED、生物标志物水平与精神病理学之间的关联。SED与血清IL6水平显著相关（RR = 1.026，95% CI 1.004；1.049，p = 0.020）和TBARS（RR = 1.077，95% CI 1.028；1.127，p = 0.002）。SED与BDNF之间的关联无统计学意义（RR = 1.031，95% CI 0.997；1.066，p = 0.077）。SED也与所有CBCL面向DSM的量表显著相关（所有p < 0.05），而血清生物标志物（即IL6、TBARS、BDNF）与特定子量表相关。此外，血清生物标志物与精神病理学领域之间的关联受SED调节，在高SED儿童中观察到心理健康问题、IL6、TBARS和BDNF之间的相关性更强。
在儿童中，SED与心理健康问题高度相关。我们的研究结果表明，这种关联可能通过对多个相互作用的神经生物学系统的影响而受到调节。
