螯合剂反复肠胃外给药对铀的分布和排泄的影响。

The effects of repeated parenteral administration of chelating agents on the distribution and excretion of uranium.

作者信息

Domingo J L, Ortega A, Llobet J M, Paternain J L, Corbella J

机构信息

Laboratory of Toxicology and Biochemistry, School of Medicine, University of Barcelona, Reus, Spain.

出版信息

Res Commun Chem Pathol Pharmacol. 1989 Apr;64(1):161-4.

PMID:2748997

Abstract

The effects of repeated ip administration of gallic acid, 4,5-dihydroxy-1,3-benzenedisulfonic acid (Tiron), diethylenetriaminepentaacetic acid (DTPA), and 5-aminosalicylic acid (5-AS) on the distribution and excretion of uranium were assessed in male Swiss mice. Only Tiron significantly increased the amount of uranium excreted into urine and feces. A significant decrease in the concentration of uranium in liver, spleen and bone was observed after administration of Tiron, whereas injection of gallic acid or DTPA resulted in a significant decrease in the concentration of the metal in the liver. The results show that Tiron was consistently the most effective chelator of those tested in the treatment of uranium poisoning after repeated daily administration of the metal.

摘要

在雄性瑞士小鼠中评估了重复腹腔注射没食子酸、4,5-二羟基-1,3-苯二磺酸（替诺）、二乙烯三胺五乙酸（DTPA）和5-氨基水杨酸（5-AS）对铀分布和排泄的影响。只有替诺显著增加了尿和粪便中排出的铀量。给予替诺后，肝脏、脾脏和骨骼中的铀浓度显著降低，而注射没食子酸或DTPA导致肝脏中金属浓度显著降低。结果表明，在每日重复给予金属后，替诺始终是所测试的治疗铀中毒的螯合剂中最有效的。