功能性FCGR2A R131H和FCGR3A F158V基因多态性与脊柱关节病、银屑病和克罗恩病中肿瘤坏死因子阻滞剂反应性之间的关联：一项荟萃分析
Associations between functional FCGR2A R131H and FCGR3A F158V polymorphisms and responsiveness to TNF blockers in spondyloarthropathy, psoriasis and Crohn's disease: a meta-analysis.
作者信息
Lee Young Ho, Choi Sung Jae, Ji Jong Dae, Song Gwan Gyu
机构信息
Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
出版信息
Pharmacogenomics. 2016 Aug;17(13):1465-77. doi: 10.2217/pgs.16.27. Epub 2016 Aug 4.
AIM
The aim of the current study was to investigate whether FCGR polymorphisms are associated with responsiveness to anti-TNF-α therapy in patients with spondyloarthropathy, psoriasis, and Crohn's disease.
MATERIALS & METHODS: We conducted a meta-analysis to evaluate the association between the functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to TNF blockers.
RESULTS
The meta-analysis indicated that responsiveness to TNF blockers was associated with the FCGR3A V allele (odds ratio: 3.308; 95% CI: 1.053-10.39; p = 0.040) and the FCGR2A RR + RH genotype (odds ratio: 3.904; p = 0.027) in patients with a follow-up time of ≥6 months.
CONCLUSION
FCGR3A V and FCGR2A R allele carriers show better responsiveness to anti-TNF-α therapy in patients with follow-up times ≥6 months.
目的
本研究旨在调查Fcγ受体（FCGR）基因多态性是否与脊柱关节病、银屑病和克罗恩病患者对抗肿瘤坏死因子-α（TNF-α）治疗的反应性相关。
材料与方法
我们进行了一项荟萃分析，以评估功能性FCGR3A F158V和FCGR2A R131H基因多态性与TNF阻滞剂反应性之间的关联。
结果
荟萃分析表明，在随访时间≥6个月的患者中，TNF阻滞剂反应性与FCGR3A V等位基因（比值比：3.308；95%置信区间：1.053 - 10.39；p = 0.040）以及FCGR2A RR + RH基因型（比值比：3.904；p = 0.027）相关。
结论
在随访时间≥6个月的患者中，FCGR3A V和FCGR2A R等位基因携带者对抗TNF-α治疗表现出更好的反应性。
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