Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, Seoul, 136-705, South Korea.
Mol Biol Rep. 2013 Aug;40(8):4985-93. doi: 10.1007/s11033-013-2599-y. Epub 2013 May 7.
The aim of this study was to determine whether the Fcγ receptors (FCGRs) polymorphisms confer susceptibility to periodontitis in ethnically different populations. We did a literature search using PubMed and Embase, and conducted a meta-analysis on the associations between the FCGR2A H131R (rs1801274), FCGR3A F158V (rs396991), and FCGR3B NA1/NA2 polymorphisms and periodontitis using allele contrast, the recessive model, the dominant model, and the homozygote contrast. A total of 17 separate comparisons with 1,421 patients with periodontitis and 1,454 controls, involving six Caucasian, six East Asian, two African and one South Asian population were considered in the meta-analysis. Meta-analysis of the FCGR2A H131R polymorphism showed no association between periodontitis and the FCGR2A R allele (OR=0.987, 95% CI=0.881-1.107, p=0.827). Stratification by ethnicity revealed an association between the RR+RH genotype with periodontitis in Caucasian population (OR=0.624, 95% CI=0.479-0.813, p=4.7×10(-5)), but not in East Asian, and African populations. Meta-analysis of the FCGR3A F158V polymorphism revealed an association between the FCGR3A V allele and periodontitis is in Caucasians (OR=1.457, 95% CI=1.014-2.092, p=0.042), but not in East Asians and Africans. In addition, analysis using the dominant model and homozygote contrast showed the same pattern for the FCGR3A V allele. Meta-analysis of the FCGR3B NA1/NA2 polymorphism using the recessive model revealed a significant association between the NA2/NA2 genotype and periodontitis in aggressive periodontitis (OR=2.853, 95% CI=1.673-4.863, 1.1×10(-5)). This meta-analysis demonstrates that the FCGR2A, and FCGR3A polymorphisms may confer susceptibility to periodontitis in Caucasians, and that the FCGR3B polymorphism may be associated with susceptibility to aggressive periodontitis.
本研究旨在确定 Fcγ 受体（FCGRs）多态性是否与不同种族人群的牙周炎易感性相关。我们使用 PubMed 和 Embase 进行文献检索，并对 FCGR2A H131R（rs1801274）、FCGR3A F158V（rs396991）和 FCGR3B NA1/NA2 多态性与牙周炎之间的关联进行荟萃分析，采用等位基因对比、隐性模型、显性模型和纯合子对比。荟萃分析共纳入了 17 项独立研究，包括 1421 例牙周炎患者和 1454 例对照，涉及 6 个白种人、6 个东亚人、2 个非洲人和 1 个南亚人群。荟萃分析结果显示，FCGR2A H131R 多态性与牙周炎之间无关联（OR=0.987，95%CI=0.881-1.107，p=0.827）。按种族分层显示，在白种人群中，RR+RH 基因型与牙周炎相关（OR=0.624，95%CI=0.479-0.813，p=4.7×10(-5)），但在东亚和非洲人群中无关联。FCGR3A F158V 多态性荟萃分析显示，FCGR3A V 等位基因与白种人牙周炎相关（OR=1.457，95%CI=1.014-2.092，p=0.042），但与东亚人和非洲人无关。此外，采用显性模型和纯合子对比分析，FCGR3A V 等位基因也呈现出相同的模式。采用隐性模型对 FCGR3B NA1/NA2 多态性进行荟萃分析显示，NA2/NA2 基因型与侵袭性牙周炎之间存在显著关联（OR=2.853，95%CI=1.673-4.863，1.1×10(-5)）。本荟萃分析表明，FCGR2A 和 FCGR3A 多态性可能与白种人牙周炎易感性相关，而 FCGR3B 多态性可能与侵袭性牙周炎易感性相关。
