Gómez Portilla Alberto, Cruz Anais, Juan Nuria, Malo Palmira, de Heredia Eduardo López, Larrañaga Maitane
HUA (Hospital Universitario de Araba), C/Olaguibel, 27, 01004 Vitoria, Spain; UPV/EHU (Universidad del País Vasco), University of the Basque Country, Vitoria, Spain.
Int J Surg Case Rep. 2016;26:121-3. doi: 10.1016/j.ijscr.2016.07.017. Epub 2016 Jul 22.
Melanoma is a health problem world-wide. Its incidence has tripled in the last decade. The main cause of death in melanoma patients is widespread metastases. It can metastasize to almost every organ. However, melanoma skeletal muscle metastases (MSMM) are exceptional, and only two cases of MSMM to rectus abdominis muscles have been previously published. Regardless of all new advances seen in melanoma therapy, cure for most MSMM is still elusive. Surgical approaches are still not well defined.
A 35-year-old woman had been previously operated of an ulcerated scapular melanoma (Clark level III, Breslow 2.3mm) in January 2014. Subsequently she underwent a sentinel lymph node which resulted negative. Twenty months later, a CT scan revealed a well-enhanced nodule of 25mm in the right rectus abdominis, without any other metastases. The PET-CT uptake was pathologic (SUV maximum of 13.16). An ultrasound-guided biopsy confirmed it was a metastatic melanoma. A radical compartmental resection of the right rectus abdominis muscle was performed. The abdominal wall was reconstructed with two polypropylene meshes buried preperitoneally. The final histologic diagnosis of the specimen proved to be a metastasis of melanoma.
Surgery is the only potentially curative therapy for patients with isolated MSMM. The ultimate goal of negative resection margins, in order to avoid local recurrences, is paramount in those difficult cases.
Radical compartmental surgery should be considered for selected stage IV melanoma patients whose disease could be amenable to complete resection, in order to extend median survival.
黑色素瘤是一个全球性的健康问题。其发病率在过去十年中增长了两倍。黑色素瘤患者的主要死因是广泛转移。它几乎可以转移到每个器官。然而,黑色素瘤骨骼肌转移(MSMM)极为罕见,此前仅有两例转移至腹直肌的MSMM病例报道。尽管黑色素瘤治疗取得了诸多新进展,但大多数MSMM患者仍难以治愈。手术方法仍未明确界定。
一名35岁女性于2014年1月接受了溃疡性肩胛黑色素瘤手术(Clark分级III级,Breslow厚度2.3mm)。随后她接受了前哨淋巴结活检,结果为阴性。二十个月后,CT扫描显示右侧腹直肌有一个25mm的强化良好的结节,无其他转移灶。PET-CT摄取呈病理性(最大SUV为13.16)。超声引导下活检证实为转移性黑色素瘤。对右侧腹直肌进行了根治性分区切除。用两块聚丙烯网片经腹膜前植入重建腹壁。标本的最终组织学诊断为黑色素瘤转移。
手术是孤立性MSMM患者唯一可能治愈的治疗方法。在这些困难病例中,为避免局部复发,实现阴性切缘的最终目标至关重要。
对于疾病可完全切除的IV期黑色素瘤患者,应考虑进行根治性分区手术,以延长中位生存期。