镨介导的羰基化合物与烯丙基卤化物的 α-区域选择性巴尔比耶反应。
α-Regioselective Barbier Reaction of Carbonyl Compounds and Allyl Halides Mediated by Praseodymium.
机构信息
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Dushu Lake Campus, Soochow University , Suzhou, 215123, People's Republic of China.
出版信息
J Org Chem. 2016 Sep 2;81(17):8070-6. doi: 10.1021/acs.joc.6b01466. Epub 2016 Aug 15.
The first utility of praseodymium as a mediating metal in the Barbier reaction of carbonyl compounds with allyl halides was reported in this paper. In contrast to the traditional metal-mediated or catalyzed Barbier reactions, exclusive α-adducts were obtained in this one-pot reaction with a broad scope of substrates and feasible reaction conditions.
本文报道了镨作为介导金属在羰基化合物与烯丙基卤化物的 Barbiere 反应中的首次应用。与传统的金属介导或催化的 Barbiere 反应相比，在这种一锅反应中，使用广泛的底物和可行的反应条件，可以得到独特的α-加合物。
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