Cosgriff T M, Morrill J C, Jennings G B, Hodgson L A, Slayter M V, Gibbs P H, Peters C J
Division of Medicine, U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21701-5011.
Rev Infect Dis. 1989 May-Jun;11 Suppl 4:S807-14. doi: 10.1093/clinids/11.supplement_4.s807.
Rift Valley fever (RVF) is an important cause of disease in animals and humans in sub-Saharan Africa. In a small percentage of human cases, the disease is complicated by hemorrhage, which often is associated with a fatal outcome. Inoculation of rhesus monkeys with the Zagazig Hospital strain of RVF virus produced a clinical picture similar to illness in humans. Ten of 17 monkeys developed clinical evidence of hemostatic impairment. When coagulation tests were performed, this group of monkeys had significant abnormalities, including evidence for disseminated intravascular coagulation. These abnormalities were much less pronounced in the remaining seven monkeys-whose only sign of illness was transient fever-and, in general, they paralleled the level of viremia and the degree of elevation in levels of serum hepatic enzymes. Autopsy of the three monkeys with severe disease revealed hepatic necrosis.
裂谷热（RVF）是撒哈拉以南非洲地区动物和人类疾病的一个重要病因。在一小部分人类病例中，该疾病会因出血而复杂化，出血往往与致命后果相关。用扎加齐格医院株裂谷热病毒接种恒河猴，产生了与人类疾病相似的临床表现。17只猴子中有10只出现了止血功能受损的临床证据。当进行凝血测试时，这群猴子有明显异常，包括弥散性血管内凝血的证据。在其余7只猴子中，这些异常不太明显，它们唯一的疾病迹象是短暂发热，总体而言，这些异常与病毒血症水平及血清肝酶升高程度平行。对3只患有严重疾病的猴子进行尸检，发现有肝坏死。
