利用树枝状聚合物聚酰胺-胺在蛋白质笼状结构热体中形成金纳米颗粒。

Using the dendritic polymer PAMAM to form gold nanoparticles in the protein cage thermosome.

作者信息

Nussbaumer Martin G, Bisig Christoph, Bruns Nico

机构信息

Department of Chemistry, University of Basel, Klingelbergstrasse 80, 4056 Basel, Switzerland and Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts 02138, USA.

Department of Chemistry, University of Basel, Klingelbergstrasse 80, 4056 Basel, Switzerland and Adolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, 1700 Fribourg, Switzerland.

出版信息

Chem Commun (Camb). 2016 Aug 18;52(69):10537-9. doi: 10.1039/c6cc04739d.

DOI:10.1039/c6cc04739d

PMID:27491621

Abstract

The chaperonin thermosome (THS) is a protein cage that lacks binding sites for metal ions and inorganic nanoparticles. However, when poly(amidoamine) (PAMAM) is encapsulated into THS, gold nanoparticles (AuNP) can be prepared in the THS. The polymer binds HAuCl4. Subsequent reduction yields nanoparticles with narrow size distribution in the protein-polymer conjugate.

摘要

伴侣蛋白热体（THS）是一种缺乏金属离子和无机纳米颗粒结合位点的蛋白质笼。然而，当聚（酰胺胺）（PAMAM）被封装到THS中时，可以在THS中制备金纳米颗粒（AuNP）。该聚合物结合四氯合金酸（HAuCl4）。随后的还原反应会在蛋白质-聚合物共轭物中产生尺寸分布狭窄的纳米颗粒。