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暴露于硫芥模拟物2-氯乙基乙基硫醚和水杨酸甲酯蒸汽后头皮毛发去污的效果。

Efficacy of scalp hair decontamination following exposure to vapours of sulphur mustard simulants 2-chloroethyl ethyl sulphide and methyl salicylate.

作者信息

Spiandore Marie, Piram Anne, Lacoste Alexandre, Prevost Philippe, Maloni Pascal, Torre Franck, Asia Laurence, Josse Denis, Doumenq Pierre

机构信息

Aix-Marseille Univ, CNRS, LCE, Marseille, France.

Aix-Marseille Univ, CNRS, LCE, Marseille, France.

出版信息

Chem Biol Interact. 2017 Apr 1;267:74-79. doi: 10.1016/j.cbi.2016.07.018. Epub 2016 Aug 1.

Abstract

Chemical warfare agents are an actual threat and victims' decontamination is a main concern when mass exposure occurs. Skin decontamination with current protocols has been widely documented, as well as surface decontamination. However, considering hair ability to trap chemicals in vapour phase, we investigated hair decontamination after exposure to sulphur mustard simulants methyl salicylate and 2-chloroethyl ethyl sulphide. Four decontamination protocols were tested on hair, combining showering and emergency decontamination (use of Fuller's earth or Reactive Skin Decontamination Lotion RSDL). Both simulants were recovered from hair after treatment, but contents were significantly reduced (42-85% content allowance). Showering alone was the least efficient protocol. Concerning 2-chloroethyl ethyl sulphide, protocols did not display significant differences in decontamination efficacy. For MeS, use of emergency decontaminants significantly increased showering efficacy (10-20% rise), underlining their usefulness before thorough decontamination. Our results highlighted the need to extensively decontaminate hair after chemical exposure. Residual amounts after decontamination are challenging, as their release from hair could lead to health issues.

摘要

化学战剂是一种实际存在的威胁,在发生大规模暴露时,对受害者进行去污是主要关注点。目前关于皮肤去污的方案已有广泛记录,表面去污也是如此。然而,考虑到头发具有在气相中捕获化学物质的能力,我们研究了在接触硫芥模拟物水杨酸甲酯和2-氯乙基乙基硫醚后头发的去污情况。在头发上测试了四种去污方案,将淋浴和应急去污(使用漂白土或活性皮肤去污洗液RSDL)相结合。处理后,两种模拟物均从头发中被检测到,但含量显著降低(含量允许范围为42%-85%)。单独淋浴是效率最低的方案。对于2-氯乙基乙基硫醚,各方案在去污效果上没有显著差异。对于水杨酸甲酯,使用应急去污剂显著提高了淋浴的效果(提高了10%-20%),这突出了它们在彻底去污之前的有用性。我们的结果强调了在化学物质暴露后对头发进行广泛去污的必要性。去污后的残留量具有挑战性,因为它们从头发中释放可能会导致健康问题。

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