Institut de Recherche Biomédicale des Armées, Département de Toxicologie et Risques Chimiques, BP73, 91223 Brétigny-sur-Orge, France; Service de Santé et de Secours Médical du Service Départemental d'Incendie et de Secours des Alpes-Maritimes, 140 avenue Maréchal de Lattre de Tassigny, BP99, 06271 Villeneuve-Loubet Cedex, France.
Institut de Recherche Biomédicale des Armées, Département de Toxicologie et Risques Chimiques, BP73, 91223 Brétigny-sur-Orge, France.
Chem Biol Interact. 2015 May 5;232:94-100. doi: 10.1016/j.cbi.2015.03.010. Epub 2015 Mar 16.
In this work, our goals were to establish whether hair decontamination by showering one hour post-exposure to the highly toxic organophosphate nerve agent VX was effective, whether it required the addition of a detergent to water and, if it could be improved by using the adsorbent Fuller's Earth (FE) or the Reactive Skin Decontamination Lotion (RSDL) 30 min prior to showering. Hair exposure to VX and decontamination was performed by using an in vitro model. Hair showering led to 72% reduction of contamination. Addition of detergent to water slightly increased the decontamination effectiveness. Hair treatment with FE or RSDL improved the decontamination rate. Combination of FE use and showering, which yielded a decontamination factor of 41, was demonstrated to be the most effective hair decontamination procedure. Hair wiping after showering was shown to contribute to hair decontamination. Altogether, our results highlighted the importance of considering hair decontamination as an important part of body surface decontamination protocols.
在这项工作中，我们的目标是确定在接触剧毒有机磷神经毒剂 VX 后一小时进行淋浴是否能有效去除毛发上的污染物，是否需要在水中添加清洁剂，以及在淋浴前 30 分钟使用吸附剂富勒土 (FE) 或反应性皮肤去污剂 (RSDL) 是否可以提高去污效果。通过体外模型进行毛发接触 VX 和去污实验。毛发淋浴可将污染减少 72%。在水中添加清洁剂可略微提高去污效果。FE 或 RSDL 处理毛发可提高去污率。FE 使用和淋浴的组合显示出最高的去污效果，其去污因子为 41。淋浴后擦拭毛发也有助于去污。总之，我们的研究结果强调了将毛发去污作为身体表面去污方案的重要组成部分的重要性。
