Hartman Jorine E, Klooster Karin, Slebos Dirk-Jan, Ten Hacken Nick H T
Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD, University of Groningen, University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands.
Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD, University of Groningen, University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands.
Respir Med. 2016 Aug;117:116-21. doi: 10.1016/j.rmed.2016.06.009. Epub 2016 Jun 9.
Bronchoscopic lung volume reduction using endobronchial valves is a promising treatment for severe emphysema patients without collateral ventilation. Physical activity is an important contributing factor for the autonomy, morbidity and mortality of these patients.
We investigated the impact of endobronchial valve treatment on physical activity in severe emphysema patients.
Physical activity was measured for 7 days by a triaxial accelerometer at baseline and 6 months follow-up after EBV treatment, and compared with standard medical care in a randomized controlled trial.
Forty-three patients (77%female, age 59 ± 9years, FEV1 30 ± 7%pred, steps 3563 ± 2213per/day) wore the accelerometer and were included in the analysis. Nineteen patients received EBV treatment and 24 standard medical care. At baseline, physical activity level was comparable between groups. After 6 months, the endobronchial valve group significantly improved compared to the controls in steps/day (+1252vs-148) and locomotion time (+17vs-2 min/day). Change in sit duration (0vs + 27 min/day) did not significantly differ.
Physical activity significantly improved after endobronchial valve treatment in severe emphysema patients. This improvement was without any specific encouragement on physical activity.
Dutch trial register: NTR2876.
对于没有侧支通气的重度肺气肿患者，使用支气管内瓣膜进行支气管镜肺减容术是一种很有前景的治疗方法。身体活动是这些患者自主性、发病率和死亡率的重要影响因素。
我们研究了支气管内瓣膜治疗对重度肺气肿患者身体活动的影响。
在一项随机对照试验中，通过三轴加速度计在基线和支气管内瓣膜治疗后6个月随访时测量7天的身体活动情况，并与标准医疗护理进行比较。
43例患者（77%为女性，年龄59±9岁，FEV1为预计值的30±7%，每天步数3563±2213步）佩戴了加速度计并纳入分析。19例患者接受了支气管内瓣膜治疗，24例接受标准医疗护理。在基线时，两组的身体活动水平相当。6个月后，支气管内瓣膜组与对照组相比，每天步数（+1252对-148）和活动时间（+17对-2分钟/天）有显著改善。久坐时间的变化（0对+27分钟/天）无显著差异。
重度肺气肿患者在接受支气管内瓣膜治疗后身体活动显著改善。这种改善没有对身体活动进行任何特定的鼓励。
荷兰试验注册：NTR2876。
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