Märkische Kliniken GmbH, Klinikum Lüdenscheid, Lüdenscheid, Germany.
Witten-Herdecke University, Witten, Germany.
Sleep Breath. 2021 Jun;25(2):727-735. doi: 10.1007/s11325-020-02176-0. Epub 2020 Aug 26.
Treatment of advanced pulmonary emphysema with endobronchial coils can improve clinical outcomes like quality of life (QOL). Yet, patients with chronic obstructive pulmonary disease (COPD) are also known to suffer from reduced sleep quality. The effect of coil therapy on sleep has not yet been investigated. The primary aim of this study was to investigate sleep efficiency before and after coil treatment. Secondly, we investigated the effects on nocturnal breathing pattern, QOL, and physical activity.
Polysomnography (PSG) testing was performed before (T0), 6 month after (T3), and 12 months after (T4) treatment with endobronchial coils. Further examinations included QOL by St George's Respiratory Questionnaire (SGRQ) and COPD assessment test (CAT), and physical activity using an accelerometer for 1 week after each visit.
Of 21 patients, 14 completed the study: 6 women; mean age 58.0 ± 4.9 years; BMI 22.6 ± 4.6 kg/m; FEV 28.6 ± 7.1% predicted; residual volume (RV) 278.2 ± 49.4% predicted. Sleep efficiency did not vary between baseline and follow-up examinations (T0 69.0 ± 15.8%; T3 70.9 ± 16.0%; T4 66.8 ± 18.9%). Non-REM respiratory rate decreased compared to baseline (T0 19.4 ± 3.9/min; T3 17.8 ± 3.5/min; T4 17.1 ± 3.1/min (p = 0.041; p = 0.030) and QOL improved meeting the minimal clinically important difference (MCID) (SGRQ, T3 -12.8 units; T4 -7.1 units; CAT: T3 -5.6 units; T4 -3.4 units). No increase in physical activity was recorded (light activity T0 31.9 ± 9.9; T3 30.8 ± 16.9; T4 26.3 ± 10.6 h/week).
Treatment with endobronchial coils did not influence objectively measured sleep quality or physical activity, but reduced nocturnal breathing frequency and improved QOL in severe emphysema patients.
ClinicalTrials.gov Identifier: NCT02399514, First Posted: March 26, 2015.
支气管内线圈治疗晚期肺气肿可以改善生活质量（QOL）等临床结果。然而，患有慢性阻塞性肺疾病（COPD）的患者也已知睡眠质量下降。线圈治疗对睡眠的影响尚未得到研究。本研究的主要目的是调查线圈治疗前后的睡眠效率。其次，我们研究了对夜间呼吸模式、生活质量和身体活动的影响。
在支气管内线圈治疗前（T0）、治疗后 6 个月（T3）和 12 个月（T4）进行多导睡眠图（PSG）检查。进一步的检查包括使用圣乔治呼吸问卷（SGRQ）和 COPD 评估测试（CAT）进行生活质量评估，以及在每次就诊后使用加速度计进行 1 周的身体活动评估。
21 名患者中，有 14 名完成了研究：6 名女性；平均年龄 58.0±4.9 岁；BMI 22.6±4.6 kg/m；FEV 28.6±7.1%预计值；残气量（RV）278.2±49.4%预计值。睡眠效率在基线和随访检查之间没有变化（T0 69.0±15.8%；T3 70.9±16.0%；T4 66.8±18.9%）。与基线相比，非 REM 呼吸频率下降（T0 19.4±3.9/min；T3 17.8±3.5/min；T4 17.1±3.1/min（p=0.041；p=0.030）），生活质量改善达到最小临床重要差异（MCID）（SGRQ，T3-12.8 单位；T4-7.1 单位；CAT：T3-5.6 单位；T4-3.4 单位）。未记录到身体活动的增加（轻度活动 T0 31.9±9.9；T3 30.8±16.9；T4 26.3±10.6 h/周）。
支气管内线圈治疗并未影响客观测量的睡眠质量或身体活动，但可降低严重肺气肿患者的夜间呼吸频率并改善生活质量。
ClinicalTrials.gov 标识符：NCT02399514，首次发布：2015 年 3 月 26 日。
