Nydegger Urs, Lung Thomas, Risch Lorenz, Risch Martin, Medina Escobar Pedro, Bodmer Thomas
Labormedizinisches Zentrum Dr. Risch and Kantonsspital Graubünden, 7000 Chur, Switzerland.
Mediators Inflamm. 2016;2016:4121837. doi: 10.1155/2016/4121837. Epub 2016 Jul 14.
We work on the assumption that four major specialities or sectors of medical laboratory assays, comprising clinical chemistry, haematology, immunology, and microbiology, embraced by genome sequencing techniques, are routinely in use. Medical laboratory markers for inflammation serve as model: they are allotted to most fields of medical lab assays including genomics. Incessant coding of assays aligns each of them in the long lists of big data. As exemplified with the complement gene family, containing C2, C3, C8A, C8B, CFH, CFI, and ITGB2, heritability patterns/risk factors associated with diseases with genetic glitch of complement components are unfolding. The C4 component serum levels depend on sufficient vitamin D whilst low vitamin D is inversely related to IgG1, IgA, and C3 linking vitamin sufficiency to innate immunity. Whole genome sequencing of microbial organisms may distinguish virulent from nonvirulent and antibiotic resistant from nonresistant varieties of the same species and thus can be listed in personal big data banks including microbiological pathology; the big data warehouse continues to grow.
基因组测序技术涵盖的临床化学、血液学、免疫学和微生物学这四个主要医学检验专业或领域在常规使用中。炎症的医学检验标志物作为范例:它们被分配到医学检验的大多数领域,包括基因组学。检验的持续编码将它们中的每一个都排列在大数据的长列表中。以包含C2、C3、C8A、C8B、CFH、CFI和ITGB2的补体基因家族为例,与补体成分基因故障相关疾病的遗传模式/风险因素正在显现。C4成分的血清水平取决于充足的维生素D,而低维生素D与IgG1、IgA和C3呈负相关,将维生素充足与先天免疫联系起来。微生物全基因组测序可以区分同一物种的有毒和无毒以及对抗生素耐药和不耐药的品种,因此可以列入包括微生物病理学在内的个人大数据库;大数据仓库持续增长。