伊朗亚兹德成年琐罗亚斯德教徒中代谢综合征的高发生率：一项横断面研究。
High frequency of metabolic syndrome in adult Zoroastrians in Yazd, Iran: a cross-sectional study.
作者信息
Afrand Mohammadhosain, Khalilzadeh Saeed Hossein, Shojaoddiny-Ardekani Ahmad, Afkhami-Ardekani Mohammad, Ariaeinejad Azita
机构信息
MD, Medical Scientific Association, Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Assistant Professor, Department of Endocrinology, Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
出版信息
Med J Islam Repub Iran. 2016 May 16;30:370. eCollection 2016.
BACKGROUND
Metabolic syndrome (MS) is a cluster of metabolic disturbances, and its prevalence is increasing worldwide. MS exhibits variations among ethnic groups. Zoroastrianism is an ethnic minority which has maintained its isolation and endogamy up to now. So, we evaluated the frequency of MS in Zoroastrians of Yazd, Iran.
METHODS
In this cross-sectional study, participants aged ≥30 years were selected using a systematic random sampling. Weight, height, body mass index (BMI), waist circumference (WC), hip circumference (HC), waistto- hip ratio (WHR) and blood pressure (BP) were measured using standard methods. Also, blood levels of glucose, triglycerides (TG), total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), urea, creatinine and uric acid (UA) were measured. Both revised National Cholesterol Education Program Adult Treatment Panel III (ATPIII) and Joint Interim Statement (JIS) criteria were used to diagnose the MS.
RESULTS
The mean±SD age of the participants (n=403) was 56.9±12.8 years. The frequency of MS was 69.7% and 74.9% based on JIS and ATPIII criteria, respectively; this was significantly different by age, marital status, job, educational level, and menopausal status (p<0.05). The most prevalent abnormal parameters of MS according to ATPIII and JIS criteria were high WC (95%) and low HDL (87.9%), respectively. Mean LDL, systolic BP, WHR, UA, urea, and creatinine were different between men and women. The difference between the age groups was statistically significant for BMI, systolic BP, diastolic BP, TG, WHR and urea (p<0.05).
CONCLUSION
This study showed a high frequency of MS in Zoroastrians of Yazd, Iran.
背景
代谢综合征（MS）是一组代谢紊乱症候群，其在全球范围内的患病率正在上升。MS在不同种族群体中表现出差异。琐罗亚斯德教是一个少数民族，至今仍保持着隔离和族内通婚。因此，我们评估了伊朗亚兹德琐罗亚斯德教徒中MS的发生率。
方法
在这项横断面研究中，采用系统随机抽样法选取年龄≥30岁的参与者。使用标准方法测量体重、身高、体重指数（BMI）、腰围（WC）、臀围（HC）、腰臀比（WHR）和血压（BP）。此外，还测量了血糖、甘油三酯（TG）、总胆固醇、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、尿素、肌酐和尿酸（UA）的血液水平。采用修订的美国国家胆固醇教育计划成人治疗小组第三次报告（ATPIII）和联合临时声明（JIS）标准来诊断MS。
结果
参与者（n = 403）的平均年龄±标准差为56.9±12.8岁。根据JIS和ATPIII标准，MS的发生率分别为69.7%和74.9%；在年龄、婚姻状况、工作、教育水平和绝经状态方面存在显著差异（p<0.05）。根据ATPIII和JIS标准，MS最常见的异常参数分别是高WC（95%）和低HDL（87.9%）。男性和女性的平均LDL、收缩压、WHR、UA、尿素和肌酐存在差异。年龄组之间在BMI、收缩压、舒张压、TG、WHR和尿素方面的差异具有统计学意义（p<0.05）。
结论
本研究表明伊朗亚兹德琐罗亚斯德教徒中MS的发生率很高。
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