Department of Environmental and Preventive Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo, Japan.
J Atheroscler Thromb. 2010 Jul 30;17(7):695-704. doi: 10.5551/jat.3517. Epub 2010 Jun 4.
The aim of this study was to clarify the relationship between alcohol intake and metabolic syndrome in Japanese men and women.
Japanese female subjects (n=11,187) were divided into non-, light (<22 g ethanol/day) and heavy (> or = 22 ethanol/day) drinkers, and Japanese male subjects (n=19,398) were divided into non-, light (<22 g ethanol/day), heavy (> or = 22 and <44 g ethanol/day) and very heavy (> or = 44 g ethanol/day) drinkers. The mean level of each variable and the prevalence of each risk factor and metabolic syndrome were compared among the groups.
In men and women, blood pressure and HDL cholesterol tended to be higher, and hemoglobin A1c tended to be lower with increased alcohol intake. Waist circumference showed U- and V-shaped relationships, and log-converted triglyceride showed J- and V-shaped relationships with alcohol intake in men and women, respectively. The prevalence of metabolic syndrome was lowest in light drinkers in men and women and was significantly higher in very heavy drinkers than in non-drinkers in men. In men, the odds ratio vs. non-drinkers for metabolic syndrome was significantly low in light drinkers, while the odds ratio was significantly high in very heavy drinkers. In women, a significantly low odds ratio vs. non-drinkers for metabolic syndrome was obtained in light drinkers.
Light drinking is associated with a lower risk of metabolic syndrome in Japanese men and women, while very heavy drinking is thought to increase the risk of metabolic syndrome in Japanese men.
本研究旨在阐明日本男性和女性饮酒与代谢综合征之间的关系。
将日本女性受试者（n=11187）分为非饮酒者、轻度饮酒者（<22 g 乙醇/天）和重度饮酒者（≥22 g 乙醇/天），日本男性受试者（n=19398）分为非饮酒者、轻度饮酒者（<22 g 乙醇/天）、重度饮酒者（≥22 和 <44 g 乙醇/天）和重度饮酒者（≥44 g 乙醇/天）。比较各组间各变量的平均水平以及各危险因素和代谢综合征的患病率。
在男性和女性中，随着饮酒量的增加，血压和高密度脂蛋白胆固醇趋于升高，而血红蛋白 A1c 趋于降低。腰围呈 U 形和 V 形关系，男性和女性的 log 转换甘油三酯分别呈 J 形和 V 形关系。男性和女性中，代谢综合征的患病率在轻度饮酒者中最低，在重度饮酒者中明显高于非饮酒者。在男性中，与非饮酒者相比，轻度饮酒者患代谢综合征的比值比显著降低，而重度饮酒者的比值比显著升高。在女性中，与非饮酒者相比，轻度饮酒者患代谢综合征的比值比显著降低。
在日本男性和女性中，轻度饮酒与代谢综合征的风险降低相关，而重度饮酒可能会增加日本男性患代谢综合征的风险。
