Oles K S, Mirza W, Penry J K
Department of Neurology, Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103.
Surg Neurol. 1989 Aug;32(2):144-51. doi: 10.1016/0090-3019(89)90203-6.
Eight cases of carbamazepine toxicity from interaction with propoxyphene are reported. Serum concentrations of carbamazepine increased up to sixfold. All patients were symptomatic and two were hospitalized. Practitioners prescribing propoxyphene acutely for pain should be aware of this significant interaction.
据报道，有8例因与丙氧芬相互作用导致卡马西平中毒的病例。卡马西平的血清浓度升高至6倍。所有患者均出现症状，其中2例住院治疗。急性开具丙氧芬用于止痛的医生应注意这种显著的相互作用。
