Haefeli W E, Meyer P G, Lüscher T F
Department of Internal Medicine, University Hospital, Basel, Switzerland.
Epilepsia. 1994 Mar-Apr;35(2):400-2. doi: 10.1111/j.1528-1157.1994.tb02451.x.
Owing to marked fluctuations in plasma concentrations, circadian CNS toxicity (maximum in the early afternoon) occurred in a 69-year-old female patient being treated with an instant-release formulation of carbamazepine (CBZ). The neurologic syndrome was reversible after administration of the same daily dose as sustained-release formulation. This case illustrates the importance of correct timing of blood sampling to detect drug-induced toxicity and of use of sustained-release formulations in antiepileptic therapy with CBZ.
由于血浆浓度的显著波动，一名69岁接受速释型卡马西平（CBZ）治疗的女性患者出现了昼夜节律性中枢神经系统毒性（午后早些时候最为严重）。在给予相同每日剂量的缓释制剂后，神经综合征得以逆转。该病例说明了在卡马西平抗癫痫治疗中，正确选择采血时间以检测药物诱导的毒性以及使用缓释制剂的重要性。
