Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.
Altakitin S.A., Rua José Gomes Ferreira, Arm. D, 2660-360 São Julião do Tojal, Lisboa, Portugal; CENIMAT/I3N, Departamento de Ciência dos Materiais, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Campus da Caparica, 2829-516 Caparica, Portugal.
Colloids Surf B Biointerfaces. 2016 Nov 1;147:81-89. doi: 10.1016/j.colsurfb.2016.07.047. Epub 2016 Jul 22.
In this study we investigated the possibility of using layer-by-layer deposition, based in natural polymers (chitosan and alginate), to control the release of different ophthalmic drugs from three types of lens materials: a silicone-based hydrogel recently proposed by our group as drug releasing soft contact lens (SCL) material and two commercially available materials: CI26Y for intraocular lens (IOLs) and Definitive 50 for SCLs. The optimised coating, consisting in one double layer of (alginate - CaCl2)/(chitosan+glyoxal) topped with a final alginate-CaCl2 layer to avoid chitosan degradation by tear fluid proteins, proved to have excellent features to control the release of the anti-inflammatory, diclofenac, while keeping or improving the physical properties of the lenses. The coating leads to a controlled release of diclofenac from SCL and IOL materials for, at least, one week. Due to its high hydrophilicity (water contact angle≈0) and biocompatibility, it should avoid the use of further surface treatments to enhance the useŕs comfort. However, the barrier effect of this coating is specific for diclofenac, giving evidence to the need of optimizing the chemical composition of the layers in view of the desired drug.
在这项研究中，我们研究了基于天然聚合物（壳聚糖和海藻酸盐）的层层沉积在控制三种类型镜片材料（我们小组最近提出的作为药物释放软隐形眼镜（SCL）材料的硅酮基水凝胶和两种市售材料：用于眼内透镜（IOLs）的 CI26Y 和用于 SCL 的 Definitive 50）中不同眼科药物释放的可能性。优化的涂层由一层（海藻酸盐-CaCl2）/（壳聚糖+乙二醛）双层组成，顶层是最终的海藻酸盐-CaCl2 层，以避免泪液蛋白降解壳聚糖，被证明具有出色的控制释放抗炎药物双氯芬酸的特性，同时保持或改善镜片的物理性能。涂层使 SCL 和 IOL 材料中的双氯芬酸至少能持续释放一周。由于其高亲水性（水接触角≈0）和生物相容性，它应该避免使用进一步的表面处理来提高使用者的舒适度。然而，这种涂层对双氯芬酸的阻隔效果是特定的，这表明需要根据所需药物优化各层的化学成分。
