Department of Applied Physics and Physico-Informatics, Faculty of Science and Technology, Keio University , 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.
ACS Appl Mater Interfaces. 2015 Mar 4;7(8):4763-71. doi: 10.1021/am508393n. Epub 2015 Feb 18.
Antifouling super-repellent surfaces inspired by Nepenthes, the pitcher plant, were designed and named slippery liquid-infused porous surfaces (SLIPS). These surfaces repel various simple and complex liquids including water and blood by maintaining a low sliding angle. Previous studies have reported the development of fluorinated SLIPS that are not biocompatible. Here, we fabricated fluid-infused films composed of biodegradable materials and a biocompatible lubricant liquid. The film was constructed using a combination of electrostatic interactions between chitosan and alginate and hydrogen-bonding between alginate and polyvinylpyrrolidone (PVPON) via the layer-by-layer self-assembly method. After chitosan and alginate were cross-linked, the PVPON was removed by increasing the pH to generate porosity from the deconstruction of the hydrogen-bonding. The porous underlayer was hydrophobized and covered by biocompatible almond oil. Blood easily flowed over this biodegradable and biocompatible SLIPS without leaving stains on the surface, and the material is environmentally durable, has a high transmittance of about 90%, and is antithrombogenic. The results of this study suggest that this SLIPS may facilitate the creation of nonfouling medical devices through a low-cost, eco-friendly, and simple process.
受猪笼草启发设计的防污超疏液表面被命名为滑流液体浸润多孔表面（SLIPS）。这些表面通过保持低滑动角来排斥各种简单和复杂的液体，包括水和血液。先前的研究报告了不具有生物相容性的氟化 SLIPS 的开发。在这里，我们制造了由可生物降解材料和生物相容性润滑剂组成的液体浸润薄膜。该薄膜通过层层自组装方法，利用壳聚糖和藻酸盐之间的静电相互作用以及藻酸盐和聚乙烯吡咯烷酮（PVPON）之间的氢键结合来构建。壳聚糖和藻酸盐交联后，通过提高 pH 值来破坏氢键以产生孔隙，从而去除 PVPON。多孔底层经过疏水化处理，并覆盖生物相容性的杏仁油。血液很容易在这种可生物降解和生物相容的 SLIPS 上流过，而不会在表面留下污渍，并且该材料具有环境耐久性、约 90%的高透光率和抗血栓形成性。这项研究的结果表明，这种 SLIPS 可能通过低成本、环保和简单的工艺促进非粘性医疗器械的创建。
