Percutaneous toxicity of ethylene glycol monomethyl ether and of dipropylene glycol monomethyl ether in the rat.
作者信息
Fairhurst S, Knight R, Marrs T C, Scawin J W, Spurlock M S, Swanston D W
机构信息
Toxicology and Pathology Sections, Chemical Defence Establishment, Salisbury, Wiltshire, U.K.
出版信息
Toxicology. 1989 Jul 17;57(2):209-15. doi: 10.1016/0300-483x(89)90166-2.
PMID:2749747
Abstract
The subacute percutaneous toxicity of dipropylene glycol monomethyl ether (DPM) in male rats dosed 5 days/week for 4 weeks under both occluded and unoccluded conditions has been assessed and compared to the percutaneous toxicity of ethylene glycol monomethyl ether (EGM). DPM caused no significant changes in the clinical chemistry, haematology, or pathology, whereas EGM caused changes in the haematology and clinical chemistry, and both testicular and bone marrow damage at doses of 1000 mg/kg per day.
摘要
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